ID   SAA2_RABIT              Reviewed;         122 AA.
AC   P22000;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Serum amyloid A-2 protein;
DE   Contains:
DE     RecName: Full=Amyloid protein AA1 {ECO:0000250|UniProtKB:P02739};
DE     AltName: Full=Protein AA1 {ECO:0000250|UniProtKB:P02739};
DE              Short=AA1 {ECO:0000250|UniProtKB:P02739};
DE   Contains:
DE     RecName: Full=Amyloid protein AA2 {ECO:0000250|UniProtKB:P02739};
DE     AltName: Full=Protein AA2 {ECO:0000250|UniProtKB:P02739};
DE              Short=AA2 {ECO:0000250|UniProtKB:P02739};
DE   Flags: Precursor;
GN   Name=SAA2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT ASP-96.
RC   TISSUE=Liver;
RX   PubMed=2259638; DOI=10.1093/nar/18.24.7447;
RA   Tatum F., Alam J., Smith A., Morgan W.T.;
RT   "Molecular cloning, nucleotide sequence heterozygosity and regulation of
RT   rabbit serum amyloid A cDNA.";
RL   Nucleic Acids Res. 18:7447-7447(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1712590; DOI=10.1016/0006-291x(91)91780-g;
RA   Ray B.K., Ray A.;
RT   "Complementary DNA cloning and nucleotide sequence of rabbit serum amyloid
RT   A protein.";
RL   Biochem. Biophys. Res. Commun. 178:68-72(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1721234; DOI=10.1111/j.1365-3083.1991.tb01597.x;
RA   Rygg M., Marhaug G., Husby G., Dowton S.B.;
RT   "Rabbit serum amyloid protein A: expression and primary structure deduced
RT   from cDNA sequences.";
RL   Scand. J. Immunol. 34:727-734(1991).
CC   -!- FUNCTION: Major acute phase reactant. {ECO:0000250|UniProtKB:P05366}.
CC   -!- SUBUNIT: Apolipoprotein of the HDL complex.
CC       {ECO:0000250|UniProtKB:P0DJI8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DJI8}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC       {ECO:0000269|PubMed:2259638}.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; X16428; CAA34451.1; -; mRNA.
DR   EMBL; X16427; CAA34450.1; -; mRNA.
DR   EMBL; S71725; AAB20617.1; -; mRNA.
DR   PIR; I46982; I46982.
DR   RefSeq; NP_001075861.1; NM_001082392.1.
DR   AlphaFoldDB; P22000; -.
DR   SMR; P22000; -.
DR   STRING; 9986.ENSOCUP00000015130; -.
DR   GeneID; 100009259; -.
DR   KEGG; ocu:100009259; -.
DR   eggNOG; ENOG502S4PB; Eukaryota.
DR   InParanoid; P22000; -.
DR   OrthoDB; 1417043at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   2: Evidence at transcript level;
KW   Acute phase; Amyloid; HDL; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250|UniProtKB:P02739"
FT   CHAIN           19..122
FT                   /note="Serum amyloid A-2 protein"
FT                   /id="PRO_0000031597"
FT   CHAIN           19..83
FT                   /note="Amyloid protein AA1"
FT                   /evidence="ECO:0000250|UniProtKB:P02739"
FT                   /id="PRO_0000450363"
FT   CHAIN           19..72
FT                   /note="Amyloid protein AA2"
FT                   /evidence="ECO:0000250|UniProtKB:P02739"
FT                   /id="PRO_0000450364"
FT   REGION          90..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         19
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P02739"
FT   VARIANT         96
FT                   /note="A -> D"
SQ   SEQUENCE   122 AA;  13451 MW;  C135BEE727C57C15 CRC64;
     MKLLSGLLLC SLVLGVSGQG WFSFIGEAVR GAGDMWRAYS DMREANYINA DKYFHARGNY
     DAAQRGPGGV WAAKVISDVR EDLQRLMGHG AEDSMADQAA NEWGRSGKDP NHFRPKGLPD
     KY