ID   SAA3_MESAU              Reviewed;         122 AA.
AC   P19453;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Serum amyloid A-3 protein;
DE   Flags: Precursor;
GN   Name=SAA3;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2164641; DOI=10.1128/mcb.10.8.4412-4414.1990;
RA   Gervais C., Suh M.;
RT   "Serum amyloid A protein-related mRNA expression in herpes simplex virus
RT   type 2-transformed hamster cells.";
RL   Mol. Cell. Biol. 10:4412-4414(1990).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex. In vitro exhibits antimicrobial activity against Escherichia
CC       coli, Streptococcus uberis and Pseudomonas aeruginosa (By similarity).
CC       {ECO:0000250|UniProtKB:Q8SQ28}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8SQ28}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC   -!- INDUCTION: Upon cytokine stimulation.
CC   -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC       extracellular accumulation in various tissues of the SAA protein. These
CC       deposits are highly insoluble and resistant to proteolysis; they
CC       disrupt tissue structure and compromise function.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; M33431; AAA37098.1; -; mRNA.
DR   PIR; A30248; A30248.
DR   RefSeq; NP_001297487.1; NM_001310558.1.
DR   AlphaFoldDB; P19453; -.
DR   SMR; P19453; -.
DR   GeneID; 101833293; -.
DR   OrthoDB; 1417043at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   2: Evidence at transcript level;
KW   Acute phase; Amyloid; HDL; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..122
FT                   /note="Serum amyloid A-3 protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000031587"
FT   REGION          100..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   122 AA;  13815 MW;  0DD15D7505518D8A CRC64;
     MKPFLAIIFC FLILGVDSQR WFQFMKEAGQ GSTDMWRAYS DMREANWKNS DKYFHARGNY
     DAAKRGPGGA WAAKVISDAR EGIQRFTGRG AADSRADQFA NKWGRSGKDP NHFRPAGLPS
     KY