SAA4_MOUSE
ID SAA4_MOUSE Reviewed; 130 AA.
AC P31532;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Serum amyloid A-4 protein {ECO:0000305};
DE AltName: Full=Amyloid A-5 protein {ECO:0000303|PubMed:9042428};
DE Flags: Precursor;
GN Name=Saa4 {ECO:0000312|MGI:MGI:98224};
GN Synonyms=Saa5 {ECO:0000303|PubMed:9042428};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=8308037; DOI=10.1016/s0021-9258(17)41827-8;
RA de Beer M.C., Kindy M.S., Lane W.S., de Beer F.C.;
RT "Mouse serum amyloid A protein (SAA5) structure and expression.";
RL J. Biol. Chem. 269:4661-4667(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RX PubMed=8661036; DOI=10.1006/geno.1996.0253;
RA de Beer M.C., de Beer F.C., Gerardot C.J., Cecil D.R., Webb N.R.,
RA Goodson M.L., Kindy M.S.;
RT "Structure of the mouse Saa4 gene and its linkage to the serum amyloid A
RT gene family.";
RL Genomics 34:139-142(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=A/J;
RX PubMed=9042428; DOI=10.1046/j.1365-3083.1997.d01-385.x;
RA Butler A., Whitehead A.S.;
RT "Structure of the mouse serum amyloid A 5 (Saa5) gene: relationship to
RT other members of the serum amyloid A family.";
RL Scand. J. Immunol. 45:160-165(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 19-74 AND 96-130.
RC STRAIN=BALB/cJ;
RX PubMed=1741755; DOI=10.1042/bj2800045;
RA de Beer M.C., Beach C.M., Shedlofsky S.I., de Beer F.C.;
RT "Identification of a novel serum amyloid A protein in BALB/c mice.";
RL Biochem. J. 280:45-49(1991).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Major acute phase reactant. {ECO:0000250|UniProtKB:P05366}.
CC -!- SUBUNIT: Apolipoprotein of the HDL complex.
CC {ECO:0000250|UniProtKB:P0DJI8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DJI8}.
CC -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC -!- INDUCTION: Upon cytokine stimulation.
CC -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC extracellular accumulation in various tissues of the SAA protein. These
CC deposits are highly insoluble and resistant to proteolysis; they
CC disrupt tissue structure and compromise function.
CC -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
CC -!- CAUTION: SAA4 used to be called SAA5. What was SAA4 is a pseudogene
CC which is now called SAA-ps. {ECO:0000305}.
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DR EMBL; U02554; AAA17564.1; -; mRNA.
DR EMBL; U40397; AAC52904.1; -; Genomic_DNA.
DR EMBL; U65403; AAB17555.1; -; Genomic_DNA.
DR EMBL; BC019212; AAH19212.1; -; mRNA.
DR CCDS; CCDS21283.1; -.
DR PIR; A53167; A53167.
DR RefSeq; NP_035446.1; NM_011316.4.
DR AlphaFoldDB; P31532; -.
DR SMR; P31532; -.
DR STRING; 10090.ENSMUSP00000006952; -.
DR PhosphoSitePlus; P31532; -.
DR CPTAC; non-CPTAC-3744; -.
DR MaxQB; P31532; -.
DR PaxDb; P31532; -.
DR PeptideAtlas; P31532; -.
DR PRIDE; P31532; -.
DR ProteomicsDB; 256581; -.
DR DNASU; 20211; -.
DR Ensembl; ENSMUST00000006952; ENSMUSP00000006952; ENSMUSG00000040017.
DR GeneID; 20211; -.
DR KEGG; mmu:20211; -.
DR UCSC; uc009gyy.1; mouse.
DR CTD; 6291; -.
DR MGI; MGI:98224; Saa4.
DR VEuPathDB; HostDB:ENSMUSG00000040017; -.
DR eggNOG; ENOG502S4PB; Eukaryota.
DR GeneTree; ENSGT00390000004737; -.
DR HOGENOM; CLU_129936_0_0_1; -.
DR InParanoid; P31532; -.
DR OMA; YPNSERY; -.
DR OrthoDB; 1417043at2759; -.
DR PhylomeDB; P31532; -.
DR TreeFam; TF332544; -.
DR BioGRID-ORCS; 20211; 1 hit in 75 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P31532; protein.
DR Bgee; ENSMUSG00000040017; Expressed in left lobe of liver and 17 other tissues.
DR Genevisible; P31532; MM.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR InterPro; IPR000096; Serum_amyloid_A.
DR Pfam; PF00277; SAA; 1.
DR PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR PRINTS; PR00306; SERUMAMYLOID.
DR SMART; SM00197; SAA; 1.
DR PROSITE; PS00992; SAA; 1.
PE 1: Evidence at protein level;
KW Acute phase; Amyloid; Direct protein sequencing; HDL; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:1741755"
FT CHAIN 19..130
FT /note="Serum amyloid A-4 protein"
FT /id="PRO_0000031592"
FT REGION 109..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 128
FT /note="Missing (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 15088 MW; 675235BD36DAEFCA CRC64;
MRLATVIVLC SLFLGVSGDG WYSFFREAVQ GTWDLWRAYR DNLEANYQNA DQYFYARGNY
EAQQRGSGGI WAAKIISTSR KYFQGLLNRY YFGIRNHGLE TLQATQKAEE WGRSGKNPNH
FRPEGLPEKF
