ID   SAA5_MESAU              Reviewed;         102 AA.
AC   P81491;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Serum amyloid A-5 protein;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=8515064;
RA   de Beer M.C., de Beer F.C., Beach C.M., Gonnerman W.A., Carreras I.,
RA   Sipe J.D.;
RT   "Syrian and Armenian hamsters differ in serum amyloid A gene expression.
RT   Identification of novel Syrian hamster serum amyloid A subtypes.";
RL   J. Immunol. 150:5361-5370(1993).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC   -!- INDUCTION: Upon cytokine stimulation.
CC   -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC       extracellular accumulation in various tissues of the SAA protein. These
CC       deposits are highly insoluble and resistant to proteolysis; they
CC       disrupt tissue structure and compromise function.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   AlphaFoldDB; P81491; -.
DR   SMR; P81491; -.
DR   STRING; 10036.XP_005085211.1; -.
DR   eggNOG; ENOG502S4PB; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Amyloid; Direct protein sequencing; HDL; Reference proteome;
KW   Secreted.
FT   CHAIN           1..102
FT                   /note="Serum amyloid A-5 protein"
FT                   /id="PRO_0000174669"
FT   REGION          68..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   102 AA;  11704 MW;  8A67FD6852866675 CRC64;
     WFSFIREAYQ GAEDMWRAYS DMKEANWRDS DKYFHARGNY DAAKRGPGGV WAAEVISDAR
     EGIQSLMGRG HEDSMADQEA NRWGRSGNDP NHYRPAGLPD KY