ID   SAA_ANAPL               Reviewed;         127 AA.
AC   P02740; Q92034;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Serum amyloid A protein;
DE            Short=SAA;
DE   Flags: Precursor;
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Pekin breed; TISSUE=Liver;
RX   PubMed=8962089; DOI=10.1073/pnas.93.25.14548;
RA   Guo J.T., Aldrich C., Mason W.S., Pugh J.C.;
RT   "Characterization of serum amyloid A protein mRNA expression and secondary
RT   amyloidosis in the domestic duck.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:14548-14553(1996).
RN   [2]
RP   PROTEIN SEQUENCE OF 19-124.
RX   PubMed=3109944; DOI=10.1016/0014-5793(87)81008-6;
RA   Ericsson L.H., Eriksen N., Walsh K.A., Benditt E.P.;
RT   "Primary structure of duck amyloid protein A. The form deposited in tissues
RT   may be identical to its serum precursor.";
RL   FEBS Lett. 218:11-16(1987).
RN   [3]
RP   PROTEIN SEQUENCE OF 19-99.
RX   PubMed=845435;
RA   Gorevic P.D., Greenwald M., Frangione B., Pras M., Franklin E.C.;
RT   "The amino acid sequence of duck amyloid A (AA) protein.";
RL   J. Immunol. 118:1113-1118(1977).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma. Also
CC       present in the liver and lung irrespective of induction.
CC   -!- INDUCTION: Upon cytokine stimulation.
CC   -!- PTM: This protein is the precursor of amyloid protein A, which is
CC       formed by the removal of approximately 3 residues from the C-terminal
CC       end.
CC   -!- POLYMORPHISM: At least two alleles exist. The sequence of the B allele
CC       is shown here.
CC   -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC       extracellular accumulation in various tissues of the SAA protein. These
CC       deposits are highly insoluble and resistant to proteolysis; they
CC       disrupt tissue structure and compromise function.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; U59909; AAC60058.1; -; Genomic_DNA.
DR   EMBL; U59908; AAC60057.1; -; mRNA.
DR   EMBL; U64985; AAC60059.1; -; Genomic_DNA.
DR   PIR; A03200; YLDKA.
DR   PIR; A27227; A27227.
DR   RefSeq; NP_001297733.1; NM_001310804.1.
DR   RefSeq; XP_005028466.2; XM_005028409.2.
DR   AlphaFoldDB; P02740; -.
DR   SMR; P02740; -.
DR   GeneID; 101798523; -.
DR   KEGG; apla:101798523; -.
DR   CTD; 6289; -.
DR   OrthoDB; 1417043at2759; -.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Amyloid; Direct protein sequencing; HDL; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:3109944,
FT                   ECO:0000269|PubMed:845435"
FT   CHAIN           19..127
FT                   /note="Serum amyloid A protein"
FT                   /id="PRO_0000031567"
FT   REGION          88..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         89
FT                   /note="G -> S (in allele A)"
FT   VARIANT         107
FT                   /note="A -> V (in allele A)"
FT   CONFLICT        81..82
FT                   /note="SD -> AN (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        93
FT                   /note="Missing (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        99
FT                   /note="T -> R (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   127 AA;  13873 MW;  6F61476AEAB9EB6F CRC64;
     MRLCICFVLL AVIVCASADN PFTRGGRFVL DAAGGAWDML RAYRDMREAN HIGADKYFHA
     RGNYDAARRG PGGAWAARVI SDARENWQGG VSGRGAEDTR ADQEANAWGR NGGDPNRYRP
     PGLPSKY