ID   SAA_BOVIN               Reviewed;         130 AA.
AC   P35541; Q32L36;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Serum amyloid A protein;
DE            Short=SAA;
DE   Contains:
DE     RecName: Full=Amyloid protein A;
DE     AltName: Full=Amyloid fibril protein AA;
DE   Flags: Precursor;
GN   Name=SAA1; Synonyms=SAA;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 19-130.
RC   TISSUE=Plasma;
RX   PubMed=1738817; DOI=10.1111/j.1365-3083.1992.tb02853.x;
RA   Rossevatin K., Andresen P.K., Sletten K., Husebekk A., Husby G.,
RA   Nordstoga K., Johnson K.H., Westermark G.T., Westermark P.;
RT   "The complete amino acid sequence of bovine serum amyloid protein A (SAA)
RT   and of subspecies of the tissue-deposited amyloid fibril protein A.";
RL   Scand. J. Immunol. 35:217-224(1992).
RN   [3]
RP   PROTEIN SEQUENCE OF 19-108.
RX   PubMed=2909653;
RA   Benson M.D., Dibartola S.P., Dwulet F.E.;
RT   "A unique insertion in the primary structure of bovine amyloid AA
RT   protein.";
RL   J. Lab. Clin. Med. 113:67-72(1989).
RN   [4]
RP   PROTEIN SEQUENCE OF 22-34.
RX   PubMed=3393848; DOI=10.1111/j.1365-3083.1988.tb02408.x;
RA   Husebekk A., Husby G., Sletten K., Skogen B., Nordstoga K.;
RT   "Characterization of bovine amyloid proteins SAA and AA.";
RL   Scand. J. Immunol. 27:739-743(1988).
RN   [5]
RP   PROTEIN SEQUENCE OF 21-66.
RX   PubMed=3791962; DOI=10.1016/0305-0491(86)90056-8;
RA   Westermark P., Johnson K.H., Westermark G.T., Sletten K., Hayden D.W.;
RT   "Bovine amyloid protein AA: isolation and amino acid sequence analysis.";
RL   Comp. Biochem. Physiol. 85B:609-614(1986).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC   -!- INDUCTION: Upon cytokine stimulation.
CC   -!- PTM: This protein is the precursor of amyloid protein A, which is
CC       formed by the removal of residues from the C-terminal end.
CC   -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC       extracellular accumulation in various tissues of the SAA protein. These
CC       deposits are highly insoluble and resistant to proteolysis; they
CC       disrupt tissue structure and compromise function.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; BC109787; AAI09788.1; -; mRNA.
DR   PIR; A60952; A60952.
DR   RefSeq; NP_001068728.1; NM_001075260.2.
DR   AlphaFoldDB; P35541; -.
DR   SMR; P35541; -.
DR   STRING; 9913.ENSBTAP00000030310; -.
DR   PaxDb; P35541; -.
DR   PRIDE; P35541; -.
DR   GeneID; 506412; -.
DR   KEGG; bta:506412; -.
DR   CTD; 6289; -.
DR   eggNOG; ENOG502S4PB; Eukaryota.
DR   HOGENOM; CLU_129936_0_0_1; -.
DR   InParanoid; P35541; -.
DR   OrthoDB; 1417043at2759; -.
DR   TreeFam; TF332544; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Amyloid; Direct protein sequencing; HDL;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:1738817,
FT                   ECO:0000269|PubMed:2909653"
FT   CHAIN           19..130
FT                   /note="Serum amyloid A protein"
FT                   /id="PRO_0000031568"
FT   CHAIN           19..108
FT                   /note="Amyloid protein A"
FT                   /id="PRO_0000031569"
FT   REGION          86..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         19
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P42819"
SQ   SEQUENCE   130 AA;  14516 MW;  EA917CD1BAB5DCEE CRC64;
     MKLFTGLILC SLVLGVHSQW MSFFGEAYEG AKDMWRAYSD MREANYKGAD KYFHARGNYD
     AAQRGPGGAW AAKVISDARE NIQRFTDPLF KGTTSGQGQE DSRADQAANE WGRSGKDPNH
     FRPAGLPDKY