ID   SAA_CANLF               Reviewed;         129 AA.
AC   P19708;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Serum amyloid A protein;
DE            Short=SAA;
DE   Contains:
DE     RecName: Full=Amyloid protein A;
DE     AltName: Full=Amyloid fibril protein AA;
DE   Flags: Precursor;
GN   Name=SAA1;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1995613; DOI=10.1016/s0021-9258(19)67824-5;
RA   Sellar G.C., Debeer M.C., Lelias J.M., Snyder P.W., Glickman L.T.,
RA   Felsburg P.J., Whitehead A.S.;
RT   "Dog serum amyloid A protein. Identification of multiple isoforms defined
RT   by cDNA and protein analyses.";
RL   J. Biol. Chem. 266:3505-3510(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 19-111.
RX   PubMed=2598632; DOI=10.1016/0305-0491(89)90030-8;
RA   Kluve-Beckerman B., Dwulet F.E., Dibartola S.P., Benson M.D.;
RT   "Primary structures of dog and cat amyloid A proteins: comparison to human
RT   AA.";
RL   Comp. Biochem. Physiol. 94B:175-183(1989).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC   -!- INDUCTION: Upon cytokine stimulation.
CC   -!- PTM: This protein is the precursor of amyloid protein A, which is
CC       formed by the removal of residues from the C-terminal end.
CC   -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC       extracellular accumulation in various tissues of the SAA protein. These
CC       deposits are highly insoluble and resistant to proteolysis; they
CC       disrupt tissue structure and compromise function.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; M59171; AAA62762.1; -; mRNA.
DR   EMBL; M59172; AAA62763.1; -; mRNA.
DR   EMBL; M59173; AAA62764.1; -; mRNA.
DR   EMBL; M59174; AAA62765.1; -; mRNA.
DR   EMBL; M59175; AAA51457.1; -; mRNA.
DR   PIR; A38645; YLDGA.
DR   PIR; B38645; B38645.
DR   PIR; C38645; C38645.
DR   PIR; D38645; D38645.
DR   PIR; E38645; E38645.
DR   RefSeq; NP_001003050.1; NM_001003050.1.
DR   RefSeq; NP_001300801.1; NM_001313872.1.
DR   RefSeq; XP_005633787.1; XM_005633730.2.
DR   AlphaFoldDB; P19708; -.
DR   SMR; P19708; -.
DR   STRING; 9615.ENSCAFP00000013430; -.
DR   PaxDb; P19708; -.
DR   PRIDE; P19708; -.
DR   Ensembl; ENSCAFT00845027545; ENSCAFP00845021672; ENSCAFG00845015397.
DR   GeneID; 403585; -.
DR   GeneID; 751814; -.
DR   KEGG; cfa:403585; -.
DR   KEGG; cfa:751814; -.
DR   VEuPathDB; HostDB:ENSCAFG00845015397; -.
DR   eggNOG; ENOG502S4PB; Eukaryota.
DR   GeneTree; ENSGT00390000004737; -.
DR   HOGENOM; CLU_129936_0_0_1; -.
DR   InParanoid; P19708; -.
DR   OMA; QEANKWG; -.
DR   OrthoDB; 1417043at2759; -.
DR   TreeFam; TF332544; -.
DR   Proteomes; UP000002254; Chromosome 21.
DR   Bgee; ENSCAFG00000015205; Expressed in retina and 46 other tissues.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Amyloid; Direct protein sequencing; HDL;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:2598632"
FT   CHAIN           19..129
FT                   /note="Serum amyloid A protein"
FT                   /id="PRO_0000031570"
FT   CHAIN           19..111
FT                   /note="Amyloid protein A"
FT                   /id="PRO_0000031571"
FT   PROPEP          112..129
FT                   /note="Often cleaved during amyloidogenesis"
FT                   /id="PRO_0000031572"
FT   REGION          92..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         19
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P42819"
FT   VARIANT         25
FT                   /note="S -> G"
FT   VARIANT         35
FT                   /note="W -> L"
FT   VARIANT         88..90
FT                   /note="LLR -> RLK"
SQ   SEQUENCE   129 AA;  14339 MW;  91B21ACBA1F998C9 CRC64;
     MKLFPGLLFC SLVLGVSGQW YSFVSEAAQG AWDMWRAYSD MREANYKNSD KYFHARGNYD
     AAQRGPGGAW AAKVISDARE NSQRITDLLR FGDSGHGAED SKADQAANEW GRSGKDPNHF
     RPAGLPDKY