ID   SAA_HORSE               Reviewed;         110 AA.
AC   P19857;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Serum amyloid A protein;
DE            Short=SAA;
DE   Contains:
DE     RecName: Full=Amyloid protein A;
DE     AltName: Full=Amyloid fibril protein AA;
GN   Name=SAA1;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Blood;
RX   PubMed=2502829; DOI=10.1111/j.1365-3083.1989.tb01195.x;
RA   Sletten K., Husebekk A., Husby G.;
RT   "The primary structure of equine serum amyloid A (SAA) protein.";
RL   Scand. J. Immunol. 30:117-122(1989).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-80.
RC   TISSUE=Liver;
RX   PubMed=3616485; DOI=10.1111/j.1365-3083.1987.tb02237.x;
RA   Sletten K., Husebekk A., Husby G.;
RT   "The amino acid sequence of an amyloid fibril protein AA isolated from the
RT   horse.";
RL   Scand. J. Immunol. 26:79-84(1987).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC   -!- INDUCTION: Upon cytokine stimulation.
CC   -!- PTM: This protein is the precursor of amyloid protein A, which is
CC       formed by the removal of residues from the C-terminal end.
CC   -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC       extracellular accumulation in various tissues of the SAA protein. These
CC       deposits are highly insoluble and resistant to proteolysis; they
CC       disrupt tissue structure and compromise function.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   PIR; A60430; A28573.
DR   AlphaFoldDB; P19857; -.
DR   SMR; P19857; -.
DR   STRING; 9796.ENSECAP00000011472; -.
DR   PaxDb; P19857; -.
DR   PeptideAtlas; P19857; -.
DR   PRIDE; P19857; -.
DR   InParanoid; P19857; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Amyloid; Direct protein sequencing; HDL; Reference proteome.
FT   CHAIN           1..110
FT                   /note="Serum amyloid A protein"
FT                   /id="PRO_0000031573"
FT   CHAIN           1..80
FT                   /note="Amyloid protein A"
FT                   /id="PRO_0000031574"
FT   REGION          73..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         16
FT                   /note="I -> L"
FT   VARIANT         44
FT                   /note="K -> Q"
FT   VARIANT         59
FT                   /note="A -> G"
FT   VARIANT         78
FT                   /note="G -> A"
SQ   SEQUENCE   110 AA;  12289 MW;  EAE7DBE7AB007E5B CRC64;
     LLSFLGEAAR GTWDMIRAYN DMREANYIGA DKYFHARGNY DAAKRGPGGA WAAKVISDAR
     ENFQRFTDRF SFGGSGRGAE DSRADQAANE WGRSGKDPNH FRPHGLPDKY