ID   SAA_MACMU               Reviewed;          76 AA.
AC   P02738;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Amyloid protein A;
DE   AltName: Full=Amyloid fibril protein AA;
GN   Name=SAA1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=4625315; DOI=10.1021/bi00766a002;
RA   Hermodson M.A., Kuhn R.W., Walsh K.A., Neurath H., Eriksen N.,
RA   Benditt E.P.;
RT   "Amino acid sequence of monkey amyloid protein A.";
RL   Biochemistry 11:2934-2938(1972).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC   -!- INDUCTION: Upon cytokine stimulation.
CC   -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC       extracellular accumulation in various tissues of the SAA protein. These
CC       deposits are highly insoluble and resistant to proteolysis; they
CC       disrupt tissue structure and compromise function.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A03198; YLMQAR.
DR   AlphaFoldDB; P02738; -.
DR   SMR; P02738; -.
DR   STRING; 9544.ENSMMUP00000014634; -.
DR   eggNOG; ENOG502S4PB; Eukaryota.
DR   InParanoid; P02738; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Amyloid; Direct protein sequencing; HDL; Reference proteome;
KW   Secreted.
FT   CHAIN           1..76
FT                   /note="Amyloid protein A"
FT                   /id="PRO_0000174668"
SQ   SEQUENCE   76 AA;  8620 MW;  A2E3905BB2E0DED4 CRC64;
     RSWFSFLGEA YDGARDMWRA YSDMKEANYK NSDKYFHARG NYDAAQRGPG GVWAAEVISD
     ARENIQKLLG HGAEDT