ID   SAA_SHEEP               Reviewed;         112 AA.
AC   P42819;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Serum amyloid A protein;
DE            Short=SAA;
GN   Name=SAA1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Plasma;
RX   PubMed=8290897; DOI=10.1111/j.1365-3083.1994.tb03344.x;
RA   Syversen P.V., Juul J., Marhaug G., Husby G., Sletten K.;
RT   "The primary structure of serum amyloid A protein in the sheep: comparison
RT   with serum amyloid A in other species.";
RL   Scand. J. Immunol. 39:88-94(1994).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC   -!- INDUCTION: Upon cytokine stimulation.
CC   -!- DISEASE: Note=Reactive, secondary amyloidosis is characterized by the
CC       extracellular accumulation in various tissues of the SAA protein. These
CC       deposits are highly insoluble and resistant to proteolysis; they
CC       disrupt tissue structure and compromise function.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   AlphaFoldDB; P42819; -.
DR   SMR; P42819; -.
DR   STRING; 9940.ENSOARP00000010561; -.
DR   eggNOG; ENOG502S4PB; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Amyloid; Direct protein sequencing; HDL;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted.
FT   CHAIN           1..112
FT                   /note="Serum amyloid A protein"
FT                   /id="PRO_0000174670"
FT   REGION          75..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..89
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:8290897"
SQ   SEQUENCE   112 AA;  12688 MW;  11A37FD59A8C1649 CRC64;
     QWLSFLGEAY EGAKDMWRAY SDMREANFKG ADKYFHARGN YDAAQRGPGG VWAAEVISNG
     REALQGITDP LFKGMTRDQV REDTKADQFA NEWGRSGKDP NHFRPPGLPD KY