SAC3C_ARATH
ID SAC3C_ARATH Reviewed; 406 AA.
AC Q67XV2; F4JCW2; Q8LAG4; Q94F11; Q9M2U9; Q9M2V0;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=SAC3 family protein C {ECO:0000303|PubMed:19843313};
GN Name=SAC3C {ECO:0000303|PubMed:19843313};
GN OrderedLocusNames=At3g54380 {ECO:0000312|Araport:AT3G54380};
GN ORFNames=T12E18.60 {ECO:0000312|EMBL:CAB81802.1},
GN T12E18.70 {ECO:0000312|EMBL:CAB81803.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAD44479.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM 2).
RA Cheuk R., Chen H., Kim C.J., Shinn P., Bowser L., Carninci P., Dale J.M.,
RA Hayashizaki Y., Hsuan V.W., Ishida J., Jones T., Kamiya A.,
RA Karlin-Neumann G., Kawai J., Lam B., Lin J., Miranda M., Narusaka M.,
RA Nguyen M., Onodera C.S., Palm C.J., Quach H.L., Sakurai T., Satou M.,
RA Seki M., Southwick A., Toriumi M., Wong C., Wu H.C., Yamada K., Yu G.,
RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=19843313; DOI=10.1111/j.1365-313x.2009.04048.x;
RA Lu Q., Tang X., Tian G., Wang F., Liu K., Nguyen V., Kohalmi S.E.,
RA Keller W.A., Tsang E.W., Harada J.J., Rothstein S.J., Cui Y.;
RT "Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components
RT and anchoring nucleoporin.";
RL Plant J. 61:259-270(2010).
CC -!- FUNCTION: Possible component of the TREX-2 complex (transcription and
CC export complex 2), a muliprotein complex that functions in docking
CC export-competent ribonucleoprotein particles (mRNPs) to the nuclear
CC entrance of the nuclear pore complex (nuclear basket). TREX-2
CC participates in mRNA export and accurate chromatin positioning in the
CC nucleus by tethering genes to the nuclear periphery.
CC {ECO:0000305|PubMed:19843313}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q67XV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q67XV2-2; Sequence=VSP_058068, VSP_058069;
CC Name=3;
CC IsoId=Q67XV2-3; Sequence=VSP_058067;
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Sac3a, sac3b and sac3c
CC triple mutants show no visible phenotype.
CC {ECO:0000269|PubMed:19843313}.
CC -!- SIMILARITY: Belongs to the SAC3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB81802.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81803.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL132971; CAB81803.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL132971; CAB81802.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE79223.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79224.1; -; Genomic_DNA.
DR EMBL; AF386980; AAK62425.1; -; mRNA.
DR EMBL; BT008465; AAP37824.1; -; mRNA.
DR EMBL; AK176716; BAD44479.1; -; mRNA.
DR EMBL; AY087832; AAM65385.1; -; mRNA.
DR PIR; T47596; T47596.
DR PIR; T47597; T47597.
DR RefSeq; NP_001190086.1; NM_001203157.1. [Q67XV2-3]
DR RefSeq; NP_851016.1; NM_180685.3. [Q67XV2-1]
DR AlphaFoldDB; Q67XV2; -.
DR SMR; Q67XV2; -.
DR STRING; 3702.AT3G54380.1; -.
DR PaxDb; Q67XV2; -.
DR PRIDE; Q67XV2; -.
DR ProteomicsDB; 232725; -. [Q67XV2-1]
DR EnsemblPlants; AT3G54380.1; AT3G54380.1; AT3G54380. [Q67XV2-1]
DR EnsemblPlants; AT3G54380.3; AT3G54380.3; AT3G54380. [Q67XV2-3]
DR GeneID; 824604; -.
DR Gramene; AT3G54380.1; AT3G54380.1; AT3G54380. [Q67XV2-1]
DR Gramene; AT3G54380.3; AT3G54380.3; AT3G54380. [Q67XV2-3]
DR KEGG; ath:AT3G54380; -.
DR Araport; AT3G54380; -.
DR TAIR; locus:2096189; AT3G54380.
DR eggNOG; KOG1860; Eukaryota.
DR InParanoid; Q67XV2; -.
DR OMA; IFTHAYN; -.
DR OrthoDB; 1593971at2759; -.
DR PhylomeDB; Q67XV2; -.
DR PRO; PR:Q67XV2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q67XV2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070390; C:transcription export complex 2; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR045107; SAC3/GANP/THP3.
DR InterPro; IPR005062; SAC3/GANP/THP3_conserved.
DR PANTHER; PTHR12436; PTHR12436; 1.
DR Pfam; PF03399; SAC3_GANP; 1.
DR PROSITE; PS50250; PCI; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..406
FT /note="SAC3 family protein C"
FT /id="PRO_0000435405"
FT DOMAIN 213..389
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..80
FT /note="MNRRNRGSSSSSSRVSNTYGNRQFSDNPRTGSGGGVNESFQRRSDAPHKRNN
FT EKDESKHKDEDPADVSLIVGTCSSMCPE -> MILPCIGK (in isoform 3)"
FT /id="VSP_058067"
FT VAR_SEQ 353..383
FT /note="ELDVESLCHECGLETCTDPDGFTVLPVKQST -> FVYFRSWMLNLYAMSVV
FT LRHVLILMGSLFYP (in isoform 2)"
FT /id="VSP_058068"
FT VAR_SEQ 384..406
FT /note="Missing (in isoform 2)"
FT /id="VSP_058069"
FT CONFLICT 10
FT /note="S -> SS (in Ref. 5; AAM65385)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="E -> K (in Ref. 5; AAM65385)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 406 AA; 46973 MW; F6C991074DA94AFF CRC64;
MNRRNRGSSS SSSRVSNTYG NRQFSDNPRT GSGGGVNESF QRRSDAPHKR NNEKDESKHK
DEDPADVSLI VGTCSSMCPE RERVTRERLR DLAVFERLYG NPSKSSTEIA VKKFCRTLSA
ADVQASDVRP LPVLEETLRY LLSLLDSKEH PFEVVHDFIF DRTRSIRQDL SIQNLANERV
IYLYEEMVKF HVISHERLQS CSGTSISSMH HLNMEQLAKT LTSLYNIYDA NRKPDYIYEN
EAEFRSLYVL LHLNPSSGVM GEPLSLWFRK LTFALVKSKE ICFVRNLLRL YRMGNYKNFL
SRTASEATYL QYCISEHHIR EMRLVAVQYI NNVCYKLQPY PLLRLSQNLK MKELDVESLC
HECGLETCTD PDGFTVLPVK QSTFRSPEDK FKVYDLIGIE RIKMSI
