SACA4_BOVIN
ID SACA4_BOVIN Reviewed; 126 AA.
AC Q32PB3;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Sperm acrosome membrane-associated protein 4;
DE Flags: Precursor;
GN Name=SPACA4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sperm surface membrane protein that may be involved in sperm-
CC egg plasma membrane adhesion and fusion during fertilization.
CC {ECO:0000250|UniProtKB:Q8TDM5}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TDM5};
CC Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q8TDM5}. Cytoplasmic
CC vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8TDM5}.
CC Note=Expressed in acrosomal matrix and outer and inner acrosomal
CC membranes. {ECO:0000250|UniProtKB:Q8TDM5}.
CC -!- SIMILARITY: Belongs to the SPACA4/bouncer family. {ECO:0000305}.
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DR EMBL; BC108186; AAI08187.1; -; mRNA.
DR RefSeq; NP_001070491.1; NM_001077023.2.
DR AlphaFoldDB; Q32PB3; -.
DR STRING; 9913.ENSBTAP00000054329; -.
DR PaxDb; Q32PB3; -.
DR Ensembl; ENSBTAT00000063625; ENSBTAP00000054329; ENSBTAG00000048127.
DR GeneID; 767953; -.
DR KEGG; bta:767953; -.
DR CTD; 171169; -.
DR VEuPathDB; HostDB:ENSBTAG00000048127; -.
DR VGNC; VGNC:35162; SPACA4.
DR eggNOG; ENOG502S5P1; Eukaryota.
DR GeneTree; ENSGT00510000049347; -.
DR HOGENOM; CLU_163755_0_0_1; -.
DR InParanoid; Q32PB3; -.
DR OMA; TSCGREE; -.
DR OrthoDB; 1493078at2759; -.
DR TreeFam; TF338445; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000048127; Expressed in spermatid and 23 other tissues.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0035036; P:sperm-egg recognition; IBA:GO_Central.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR046354; SPACA4/Bouncer.
DR PANTHER; PTHR47613; PTHR47613; 1.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell membrane; Cytoplasmic vesicle; Disulfide bond;
KW Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Reference proteome;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..97
FT /note="Sperm acrosome membrane-associated protein 4"
FT /id="PRO_0000252448"
FT PROPEP 98..126
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000252449"
FT DOMAIN 23..97
FT /note="UPAR/Ly6"
FT LIPID 97
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 23..47
FT /evidence="ECO:0000250|UniProtKB:P13987"
FT DISULFID 26..34
FT /evidence="ECO:0000250|UniProtKB:P13987"
FT DISULFID 41..65
FT /evidence="ECO:0000250|UniProtKB:P13987"
FT DISULFID 71..90
FT /evidence="ECO:0000250|UniProtKB:P13987"
FT DISULFID 91..96
FT /evidence="ECO:0000250|UniProtKB:P13987"
SQ SEQUENCE 126 AA; 12964 MW; FD06B31DFACCAA90 CRC64;
MVLGWLPLLV MVLAPGTTGV KDCVFCELTD STSCPGTSMR CGDDEDCFTG HGVAPGVGPI
INKGCVHATS CGHEEPINYM GVTYSLTTNC CTGHMCNGAP DPTRGRLAGA AASLALGVLL
LLQHVL
