ID   SACR_LACLL              Reviewed;         318 AA.
AC   Q04939;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Sucrose operon repressor;
DE   AltName: Full=Scr operon regulatory protein;
GN   Name=sacR;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=6F3;
RX   PubMed=7793910; DOI=10.1128/aem.61.3.1082-1089.1995;
RA   Siegers K., Entian K.-D.;
RT   "Genes involved in immunity to the lantibiotic nisin produced by
RT   Lactococcus lactis 6F3.";
RL   Appl. Environ. Microbiol. 61:1082-1089(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
RC   STRAIN=NIZO R5;
RX   PubMed=1330831; DOI=10.1016/0378-1119(92)90161-h;
RA   Rauch P.J., de Vos W.M.;
RT   "Transcriptional regulation of the Tn5276-located Lactococcus lactis
RT   sucrose operon and characterization of the sacA gene encoding sucrose-6-
RT   phosphate hydrolase.";
RL   Gene 121:55-61(1992).
CC   -!- FUNCTION: This protein may control the expression of the genes that are
CC       involved in the transport and catabolism of sucrose.
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DR   EMBL; U17255; AAC43330.1; -; Genomic_DNA.
DR   EMBL; M96669; AAA25219.1; -; Genomic_DNA.
DR   PIR; JH0755; JH0755.
DR   AlphaFoldDB; Q04939; -.
DR   SMR; Q04939; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR025997; SBP_2_dom.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13407; Peripla_BP_4; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..318
FT                   /note="Sucrose operon repressor"
FT                   /id="PRO_0000107998"
FT   DOMAIN          1..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   VARIANT         27
FT                   /note="Y -> C (in strain: NIZO R5)"
SQ   SEQUENCE   318 AA;  35671 MW;  D1D53E20B2F9A263 CRC64;
     MIKLEDVANK AGVSVTTVSR VINRKGYLSD ATISKVEKAM QDLHYIPNAA ARSLQGKSLK
     LIGLVFPTIK NIFYAELIEK IEQALFIRGY KAMLATTEHD EQKERDYLAL LLSNQVDGII
     YGSHNLKAHD YIAIEAPIVA FDRLLTPETT VVSSDNFEGG ILATKALINS GSKKIAIFTG
     NDNTNSPTYL RRDGYLLELE RNQLKTHIIK IPSQWTLLRK KVEIKKILEN NDFDGVFCTD
     DLTAILVKDL ASNLKKSLNV VGFDGTEFIE NYYPNLTTIK QPINDLAELL VDLIIRKIDG
     DNIDITYQLP VQLHYGID