SACS_MOUSE
ID SACS_MOUSE Reviewed; 4582 AA.
AC Q9JLC8; Q3TUF2; Q6A007; Q8BQT3; Q8C764; Q8CAJ4;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=Sacsin;
DE AltName: Full=DnaJ homolog subfamily C member 29;
DE Short=DNAJC29;
GN Name=Sacs; Synonyms=Kiaa0730;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10655055; DOI=10.1038/72769;
RA Engert J.C., Berube P., Mercier J., Dore C., Lepage P., Ge B.,
RA Bouchard J.-P., Mathieu J., Melancon S.B., Schalling M., Lander E.S.,
RA Morgan K., Hudson T.J., Richter A.;
RT "ARSACS, a spastic ataxia common in northeastern Quebec, is caused by
RT mutations in a new gene encoding an 11.5-kb ORF.";
RL Nat. Genet. 24:120-125(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3559-4582.
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1471 (ISOFORM 2), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-768 (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-178 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Head, Hypothalamus, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=19208651; DOI=10.1093/hmg/ddp067;
RA Parfitt D.A., Michael G.J., Vermeulen E.G., Prodromou N.V., Webb T.R.,
RA Gallo J.M., Cheetham M.E., Nicoll W.S., Blatch G.L., Chapple J.P.;
RT "The ataxia protein sacsin is a functional co-chaperone that protects
RT against polyglutamine-expanded ataxin-1.";
RL Hum. Mol. Genet. 18:1556-1565(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2513; THR-2518 AND THR-4263,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Co-chaperone which acts as a regulator of the Hsp70 chaperone
CC machinery and may be involved in the processing of other ataxia-linked
CC proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Predominantly
CC cytoplasmic, a small portion is present in the nucleus and also shows a
CC partial mitochondrial overlap with the mitochondrial marker Hsp60.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9JLC8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9JLC8-2; Sequence=VSP_022326;
CC Name=3;
CC IsoId=Q9JLC8-3; Sequence=VSP_022327;
CC -!- TISSUE SPECIFICITY: Brain (at protein level).
CC {ECO:0000269|PubMed:19208651}.
CC -!- DOMAIN: The ubiquitin-like domain mediates interaction with the
CC proteasome. {ECO:0000250}.
CC -!- DOMAIN: The J domain is functional and is able to stimulate E.coli dnaK
CC ATPase activity. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32757.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF193557; AAF31263.1; -; Genomic_DNA.
DR EMBL; AC124555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC138718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK173011; BAD32289.1; -; mRNA.
DR EMBL; AK038655; BAC30083.1; -; mRNA.
DR EMBL; AK046501; BAC32757.1; ALT_INIT; mRNA.
DR EMBL; AK052467; BAC35006.1; -; mRNA.
DR EMBL; AK160797; BAE36019.1; -; mRNA.
DR CCDS; CCDS88683.1; -. [Q9JLC8-1]
DR RefSeq; NP_766397.2; NM_172809.3.
DR BMRB; Q9JLC8; -.
DR SMR; Q9JLC8; -.
DR BioGRID; 206063; 4.
DR IntAct; Q9JLC8; 1.
DR STRING; 10090.ENSMUSP00000086816; -.
DR GlyConnect; 2689; 2 N-Linked glycans (1 site).
DR GlyGen; Q9JLC8; 1 site, 2 N-linked glycans (1 site).
DR iPTMnet; Q9JLC8; -.
DR PhosphoSitePlus; Q9JLC8; -.
DR SwissPalm; Q9JLC8; -.
DR EPD; Q9JLC8; -.
DR MaxQB; Q9JLC8; -.
DR PaxDb; Q9JLC8; -.
DR PeptideAtlas; Q9JLC8; -.
DR PRIDE; Q9JLC8; -.
DR ProteomicsDB; 256912; -. [Q9JLC8-1]
DR ProteomicsDB; 256913; -. [Q9JLC8-2]
DR ProteomicsDB; 256914; -. [Q9JLC8-3]
DR GeneID; 50720; -.
DR KEGG; mmu:50720; -.
DR CTD; 26278; -.
DR MGI; MGI:1354724; Sacs.
DR eggNOG; ENOG502QQPY; Eukaryota.
DR InParanoid; Q9JLC8; -.
DR OrthoDB; 1277at2759; -.
DR PhylomeDB; Q9JLC8; -.
DR BioGRID-ORCS; 50720; 3 hits in 59 CRISPR screens.
DR ChiTaRS; Sacs; mouse.
DR PRO; PR:Q9JLC8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9JLC8; protein.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0051087; F:chaperone binding; ISO:MGI.
DR GO; GO:0030544; F:Hsp70 protein binding; ISO:MGI.
DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; ISA:MGI.
DR GO; GO:0070628; F:proteasome binding; ISO:MGI.
DR GO; GO:0090084; P:negative regulation of inclusion body assembly; ISO:MGI.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR007842; HEPN_dom.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF05168; HEPN; 1.
DR SMART; SM00748; HEPN; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR SUPFAM; SSF55874; SSF55874; 3.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50910; HEPN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Chaperone; Cytoplasm; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..4582
FT /note="Sacsin"
FT /id="PRO_0000097564"
FT DOMAIN 7..84
FT /note="Ubiquitin-like"
FT DOMAIN 4309..4396
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT DOMAIN 4454..4570
FT /note="HEPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00105"
FT REGION 4249..4274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4408..4430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4254..4272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 945
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZJ4"
FT MOD_RES 1781
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZJ4"
FT MOD_RES 2513
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2518
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 3437
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZJ4"
FT MOD_RES 4263
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 4266
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZJ4"
FT VAR_SEQ 1..752
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022326"
FT VAR_SEQ 1..6
FT /note="METKFQ -> MGD (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022327"
FT CONFLICT 4..6
FT /note="KFQ -> EET (in Ref. 4; BAE36019)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="V -> I (in Ref. 4; BAC35006/BAE36019)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="P -> H (in Ref. 4; BAC32757)"
FT /evidence="ECO:0000305"
FT CONFLICT 731..744
FT /note="GRPCTQLQLLNPER -> AQQLLWGYSGRITD (in Ref. 4;
FT BAC32757)"
FT /evidence="ECO:0000305"
FT CONFLICT 732..768
FT /note="RPCTQLQLLNPERFARLIKEVMNTFWPGRELVVQWYP -> YVKHDLLTTLE
FT RISLAYSGNKNSDSPSRRSPSAVTCK (in Ref. 4; BAE36019)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 4582 AA; 520685 MW; 2409B6DA64905B48 CRC64;
METKFQRWVR VTVLRGCVGC RTVAVPATAT GRDLKERIFA ETSFPVAEQR LWRGDREVPD
WIKIGDLTSK TCHLFVNLQS KGLKGGGRFG QTTPPLVDFL KDILRRYPEG GQILKELIQN
AEDAGATEVK FLYDETQYGT ETLWSKDMAQ YQGSALYVYN NAVFTPEDWH GIQEIARSRK
KDDPLKVGRF GIGFNSVYHI TDVPCIFSGD QIGMLDPHQT LFGPHESGQC WNLKDDIKEI
NELPDQFAPF IGVFGSTKET FTNGSFPGTF FRFPLRLQPS QLSSNLYTKQ KVLELFDSFR
ADADTVLLFL KSVQAVSLHV READGTEKLV FRVTASENKA LKHERPNSIK ILGTAISNYC
KKIPSNSVTC VTYHINIVLE DESTKDAQKT SWLVCNSVGG RGISSKLDSL ADELKFVPII
GLAMPLSGKD EENGAISDFS GKAFCFLPLP PGEESRTGLP VHISGFFGLT DNRRSIKWRE
LDQWRDPAAL WNEYLIVNVV PKTYATLILD SIKRLETEKS SDFPLSVDTI YKLWPEASKV
KAHWHPVLGP LFSELFQHAV IYSIGGEWVK LEQVHFSELD GSLESTRSVL NYLQSSGKQI
AKVPGNLAAA VQLSAASATS SASPVRKVTP AWVRQVLRKC AHLGSAEEKL HLLEFVLSDQ
AYSELLGLEL LPLQSGAFVP FSSSVSDQDV VYITSEEFPR SLFPGLEARL ILENLKPHLL
AALKEAAQTR GRPCTQLQLL NPERFARLIK EVMNTFWPGR ELVVQWYPFS EDKRHPSLSW
LKMVWKNLYI HFSEDLTLFD EMPLIPRTLL NEDQTCVELI RLRIPSVVIL DDETEAQLPE
FLADIVQKLG GIVLKRLDTS IQHPLVKKYI HSPLPSAILQ IMEKIPLQKL CNQIASLLPT
HKDALRKFLA SLTDTSEKEK RIIQELTIFK RINHSSDQGI SSYTKLKGCK VLDHTAKLPT
DLRLSVSVID SSDEATIRLA NMLKIEKLKT TSCLKFVLKD IGNAFYTQEE VTQLMLWILE
NLSSLKNENS NVLDWLMPLK FIHMSQGHVV AAGDLFDPDI EVLRDLFYNE EEACFPPTIF
TSPDILHSLR QIGLKNESSL KEKDVVQVAR KIEALQVSSC QNQDVLMKKA KTLLLVLNKN
QTLLQSSEGK MALKKIKWVP ACKERPPNYP GSLVWKGDLC NLCAPPDMCD AAHAVLVGSS
LPLVESVHVN LEQALSIFTK PTINAVLKHF KTVVDWYTSK TFSDEDYYQF QHILLEIYGF
MHDHLSEGKD SFKALKFPWV WTGKNFCPLA QAVIKPTHDL DLQPYLYNVP KTMAKFHQLF
KACGSIEELT SDHISMVIQK VYLKSDQELS EEESKQNLHL MLNIMRWLYS NQIPASPNTP
VPIYHSRNPS KLVMKPIHEC CYCDIKVDDL NDLLEDSVEP IILVHEDIPM KTAEWLKVPC
LSTRLINPEN MGFEQSGQRE PLTVRIKNIL EEYPSVSDIF KELLQNADDA NATECSFMID
MRRNMDIREN LLDPGMAACH GPALWSFNNS EFSDSDFLNI TRLGESLKRG EVDKVGKFGL
GFNSVYHITD IPIIMSREFM IMFDPNINHI SKHIKDRSNP GIKINWSKQQ KRLRKFPNQF
KPFIDVFGCQ LPLAVEAPYS YNGTLFRLSF RTQQEAKVSE VSSTCYNTAD IYSLVDEFSL
CGHRLIIFTQ SVNSMYLKYL KIEETNPSLA QDTIIIKKKV CPSKALNAPV LSVLKEAAKL
MKTCSSSNKK LPTDVPKSSC ILQITVEEFH HVFRRIADLQ SPLFRGPDDD PATLFEMAKS
GQSKKPSDEL PQKTVDCTTW LICTCMDTGE ALKFSLNESG RRLGLVPCGA VGVLLHETQE
QKWTVKPHIG EVFCYLPLRI KTGLPIHING CFAVTSNRKE IWKTDTKGRW NTTFMRHVIV
KAYLQALSVL RDLAIGGELT DYTYYAVWPD PDLVHDDFSV ICKGFYEDIA HGKGKELTRV
FSDGSMWVSM KNVRFLDDSI LQRKDVGSAA FKIFLKYLKK TGSKNLCAVE LPSSVKAGFE
EAGCKQILLE NTFSEKQFFS EVFFPNIQEI EAELRDPLMN FVLNEKLDEF SGILRVTPCV
PCSLEGHPLV LPSRLIHPEG RVAKLFDTKD GRFPYGSTQD YLNPIILIKL VQLGMAKDDI
LWDDMLERAE SVAEINKSDH AAACLRSSIL LSLIDEKLKI KDPRAKDFAA KYQTIPFLPF
LTKPAGFSLE WKGNSFKPET MFAATDIYTA EYQDIVCLLQ PILNENSHSF RGCGSVSLAV
KEFLGLLKKP TVDLVINQLK QVAKSVDDGI TLYQENITNA CYKYLHEAVL QNEMAKATII
EKLKPFCFIL VENVYVESEK VSFHLNFEAA PYLYQLPNKY KNNFRELFES VGVRQSFTVE
DFALVLESID QERGKKQITE ENFQLCRRII SEGIWSLIRE KRQEFCEKNY GKILLPDTNL
LLLPAKSLCY NDCPWIKVKD STVKYCHADI PREVAVKLGA IPKRHKALER YASNICFTAL
GTEFGQKEKL TSRIKSILNA YPSEKEMLKE LLQNADDAKA TEICFVFDPR QHPVDRIFDD
KWAPLQGPAL CVYNNQPFTE DDVRGIQNLG KGTKEGNPCK TGHYGIGFNS VYHITDCPSF
ISGNDILGIF DPHARYAPGA TSVSPGRMFR DLDADFRTQF SDVLDLYLGN HFKLDNCTMF
RFPLRNAEMA QVSEISSVPS SDRMVQNLLD KLRSDGAELL MFLNHMEKIS ICEIDKATGG
LNVLYSVKGK ITDGDRLKRK QFHASVIDSV TKKRQLKDIP VQQITYTMDT EDSEGNLTTW
LICNRSGFSS MEKVSKSVIS AHKNQDITLF PRGGVAACIT HNYKKPHRAF CFLPLSLETG
LPFHVNGHFA LDSARRNLWR DDNGVGVRSD WNNSLMTALI APAYVELLIQ LKKRYFPGSD
PTLSVLQNTP IHVVKDTLKK FLSFFPVNRL DLQPDLYCLV KALYSCIHED MKRLLPVVRA
PNIDGSDLHS AVIITWINMS TSNKTRPFFD NLLQDELQHL KNADYNITTR KTVAENVYRL
KHLLLEIGFN LVYNCDETAN LYHCLVDADI PVSYVTPADV RSFLMTFSSP DTNCHIGKLP
CRLQQTNLKL FHSLKLLVDY CFKDAEESEF EVEGLPLLIT LDSVLQIFDG KRPKFLTTYH
ELIPSRKDLF MNTLYLKYSS VLLNCKVAKV FDISSFADLL SSVLPREYKT KNCAKWKDNF
ASESWLKNAW HFISESVSVT DDQEEPKPAF DVIVDILKDW ALLPGTKFTV STSQLVVPEG
DVLIPLSLMH IAVFPNAQSD KVFHALMKAG CIQLALNKIC SKDSALVPLL SCHTANIDSP
ASILKAVHYM VQTSTFRTEK LMENDFEALL MYFNCNLSHL MSQDDIKILK SLPCYKSISG
RYMSIAKFGT CYVLTKSIPS AEVEKWTQSS SSAFLEEKVH LKELYEVLGC VPVDDLEVYL
KHLLPKIENL SYDAKLEHLI YLKNRLASIE EPSEIKEQLF EKLESLLIIH DANNRLKQAK
HFYDRTVRVF EVMLPEKLFI PKEFFKKLEQ VIKPKNQAAF MTSWVEFLRN IGLKYALSQQ
QLLQFAKEIS VRANTENWSK ETLQSTVDIL LHHIFQERMD LLSGNFLKEL SLIPFLCPER
APAEYIRFHP QYQEVNGTLP LIKFNGAQVN PKFKQCDVLQ LLWTSCPILP EKATPLSIKE
QEGSDLAPQE QLEQVLNMLN VNLDPPLDKV INNCRNICNI TTLDEEMVKT RAKVLRSIYE
FLSAEKREFR FQLRGVAFVM VEDGWKLLKP EEVVINLEYE ADFKPYLYKL PLELGTFHQL
FKHLGTEDII STKQYVEVLS RIFKSSEGKQ LDPNEMRTVK RVVSGLFKSL QNDSVKVRSD
LENARDLALY LPSQDGKLVK SSILVFDDAP HYKSRIQGNI GVQMLVDLSQ CYLGKDHGFH
TKLIMLFPQK LRPRLLSSIL EEQLDEETPK VCQFGALCSL QGRLQLLLSS EQFITGLIRI
MKHENDNAFL ANEEKAIRLC KALREGLKVS CFEKLQTTLR VKGFNPIPHS RSETFAFLKR
FGNAVILLYI QHSDSKDINF LLALAMTLKS ATDNLISDTS YLIAMLGCND IYRISEKLDS
LGVKYDSSEP SKLELPMPGT PIPAEIHYTL LMDPMNVFYP GEYVGYLVDA EGGDIYGSYQ
PTYTYAIIVQ EVEREDADNT SFLGKIYQID IGYSEYKIVS SLDLYKFSRP DESSQNRDSA
PTTPTSPTEF LTPGLRSIPP LFSGKESHKS PSTKHHSPRK LKVNALPEIL KEVTSVVEQA
WKLPESERKK IIRRLYLKWH PDKNPENHDI ANEVFKHLQN EINRLEKQAF LDQNADRASR
RTFSTSASRF QSDKYSFQRF YTSWNQEATS HKSERQQQSK EKCPPSAGQT YSQRFFVPPT
FKSVGNPVEA RRWLRQARAN FSAARNDLHK NANEWVCFKC YLSTKLALIA ADYAVRGKSD
KDVKPTALAQ KIEEYSQQLE GLTNDVHTLE AYGVDSLKTR YPDLLPFPQI PNDRFTSEVA
MRVMECTACI IIKLENFIQQ KV