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SACS_MOUSE
ID   SACS_MOUSE              Reviewed;        4582 AA.
AC   Q9JLC8; Q3TUF2; Q6A007; Q8BQT3; Q8C764; Q8CAJ4;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 141.
DE   RecName: Full=Sacsin;
DE   AltName: Full=DnaJ homolog subfamily C member 29;
DE            Short=DNAJC29;
GN   Name=Sacs; Synonyms=Kiaa0730;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10655055; DOI=10.1038/72769;
RA   Engert J.C., Berube P., Mercier J., Dore C., Lepage P., Ge B.,
RA   Bouchard J.-P., Mathieu J., Melancon S.B., Schalling M., Lander E.S.,
RA   Morgan K., Hudson T.J., Richter A.;
RT   "ARSACS, a spastic ataxia common in northeastern Quebec, is caused by
RT   mutations in a new gene encoding an 11.5-kb ORF.";
RL   Nat. Genet. 24:120-125(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3559-4582.
RC   TISSUE=Fetal brain;
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1471 (ISOFORM 2), NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 1-768 (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 1-178 (ISOFORM 3).
RC   STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Head, Hypothalamus, and Lung;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=19208651; DOI=10.1093/hmg/ddp067;
RA   Parfitt D.A., Michael G.J., Vermeulen E.G., Prodromou N.V., Webb T.R.,
RA   Gallo J.M., Cheetham M.E., Nicoll W.S., Blatch G.L., Chapple J.P.;
RT   "The ataxia protein sacsin is a functional co-chaperone that protects
RT   against polyglutamine-expanded ataxin-1.";
RL   Hum. Mol. Genet. 18:1556-1565(2009).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2513; THR-2518 AND THR-4263,
RP   AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Co-chaperone which acts as a regulator of the Hsp70 chaperone
CC       machinery and may be involved in the processing of other ataxia-linked
CC       proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Predominantly
CC       cytoplasmic, a small portion is present in the nucleus and also shows a
CC       partial mitochondrial overlap with the mitochondrial marker Hsp60.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9JLC8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9JLC8-2; Sequence=VSP_022326;
CC       Name=3;
CC         IsoId=Q9JLC8-3; Sequence=VSP_022327;
CC   -!- TISSUE SPECIFICITY: Brain (at protein level).
CC       {ECO:0000269|PubMed:19208651}.
CC   -!- DOMAIN: The ubiquitin-like domain mediates interaction with the
CC       proteasome. {ECO:0000250}.
CC   -!- DOMAIN: The J domain is functional and is able to stimulate E.coli dnaK
CC       ATPase activity. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC32757.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF193557; AAF31263.1; -; Genomic_DNA.
DR   EMBL; AC124555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC138718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK173011; BAD32289.1; -; mRNA.
DR   EMBL; AK038655; BAC30083.1; -; mRNA.
DR   EMBL; AK046501; BAC32757.1; ALT_INIT; mRNA.
DR   EMBL; AK052467; BAC35006.1; -; mRNA.
DR   EMBL; AK160797; BAE36019.1; -; mRNA.
DR   CCDS; CCDS88683.1; -. [Q9JLC8-1]
DR   RefSeq; NP_766397.2; NM_172809.3.
DR   BMRB; Q9JLC8; -.
DR   SMR; Q9JLC8; -.
DR   BioGRID; 206063; 4.
DR   IntAct; Q9JLC8; 1.
DR   STRING; 10090.ENSMUSP00000086816; -.
DR   GlyConnect; 2689; 2 N-Linked glycans (1 site).
DR   GlyGen; Q9JLC8; 1 site, 2 N-linked glycans (1 site).
DR   iPTMnet; Q9JLC8; -.
DR   PhosphoSitePlus; Q9JLC8; -.
DR   SwissPalm; Q9JLC8; -.
DR   EPD; Q9JLC8; -.
DR   MaxQB; Q9JLC8; -.
DR   PaxDb; Q9JLC8; -.
DR   PeptideAtlas; Q9JLC8; -.
DR   PRIDE; Q9JLC8; -.
DR   ProteomicsDB; 256912; -. [Q9JLC8-1]
DR   ProteomicsDB; 256913; -. [Q9JLC8-2]
DR   ProteomicsDB; 256914; -. [Q9JLC8-3]
DR   GeneID; 50720; -.
DR   KEGG; mmu:50720; -.
DR   CTD; 26278; -.
DR   MGI; MGI:1354724; Sacs.
DR   eggNOG; ENOG502QQPY; Eukaryota.
DR   InParanoid; Q9JLC8; -.
DR   OrthoDB; 1277at2759; -.
DR   PhylomeDB; Q9JLC8; -.
DR   BioGRID-ORCS; 50720; 3 hits in 59 CRISPR screens.
DR   ChiTaRS; Sacs; mouse.
DR   PRO; PR:Q9JLC8; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9JLC8; protein.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0051087; F:chaperone binding; ISO:MGI.
DR   GO; GO:0030544; F:Hsp70 protein binding; ISO:MGI.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; ISA:MGI.
DR   GO; GO:0070628; F:proteasome binding; ISO:MGI.
DR   GO; GO:0090084; P:negative regulation of inclusion body assembly; ISO:MGI.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR007842; HEPN_dom.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF05168; HEPN; 1.
DR   SMART; SM00748; HEPN; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   SUPFAM; SSF55874; SSF55874; 3.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS50910; HEPN; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative splicing; Chaperone; Cytoplasm; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..4582
FT                   /note="Sacsin"
FT                   /id="PRO_0000097564"
FT   DOMAIN          7..84
FT                   /note="Ubiquitin-like"
FT   DOMAIN          4309..4396
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   DOMAIN          4454..4570
FT                   /note="HEPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00105"
FT   REGION          4249..4274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4408..4430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4254..4272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         945
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZJ4"
FT   MOD_RES         1781
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZJ4"
FT   MOD_RES         2513
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         2518
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         3437
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZJ4"
FT   MOD_RES         4263
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         4266
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZJ4"
FT   VAR_SEQ         1..752
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_022326"
FT   VAR_SEQ         1..6
FT                   /note="METKFQ -> MGD (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_022327"
FT   CONFLICT        4..6
FT                   /note="KFQ -> EET (in Ref. 4; BAE36019)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        58
FT                   /note="V -> I (in Ref. 4; BAC35006/BAE36019)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        224
FT                   /note="P -> H (in Ref. 4; BAC32757)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        731..744
FT                   /note="GRPCTQLQLLNPER -> AQQLLWGYSGRITD (in Ref. 4;
FT                   BAC32757)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        732..768
FT                   /note="RPCTQLQLLNPERFARLIKEVMNTFWPGRELVVQWYP -> YVKHDLLTTLE
FT                   RISLAYSGNKNSDSPSRRSPSAVTCK (in Ref. 4; BAE36019)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   4582 AA;  520685 MW;  2409B6DA64905B48 CRC64;
     METKFQRWVR VTVLRGCVGC RTVAVPATAT GRDLKERIFA ETSFPVAEQR LWRGDREVPD
     WIKIGDLTSK TCHLFVNLQS KGLKGGGRFG QTTPPLVDFL KDILRRYPEG GQILKELIQN
     AEDAGATEVK FLYDETQYGT ETLWSKDMAQ YQGSALYVYN NAVFTPEDWH GIQEIARSRK
     KDDPLKVGRF GIGFNSVYHI TDVPCIFSGD QIGMLDPHQT LFGPHESGQC WNLKDDIKEI
     NELPDQFAPF IGVFGSTKET FTNGSFPGTF FRFPLRLQPS QLSSNLYTKQ KVLELFDSFR
     ADADTVLLFL KSVQAVSLHV READGTEKLV FRVTASENKA LKHERPNSIK ILGTAISNYC
     KKIPSNSVTC VTYHINIVLE DESTKDAQKT SWLVCNSVGG RGISSKLDSL ADELKFVPII
     GLAMPLSGKD EENGAISDFS GKAFCFLPLP PGEESRTGLP VHISGFFGLT DNRRSIKWRE
     LDQWRDPAAL WNEYLIVNVV PKTYATLILD SIKRLETEKS SDFPLSVDTI YKLWPEASKV
     KAHWHPVLGP LFSELFQHAV IYSIGGEWVK LEQVHFSELD GSLESTRSVL NYLQSSGKQI
     AKVPGNLAAA VQLSAASATS SASPVRKVTP AWVRQVLRKC AHLGSAEEKL HLLEFVLSDQ
     AYSELLGLEL LPLQSGAFVP FSSSVSDQDV VYITSEEFPR SLFPGLEARL ILENLKPHLL
     AALKEAAQTR GRPCTQLQLL NPERFARLIK EVMNTFWPGR ELVVQWYPFS EDKRHPSLSW
     LKMVWKNLYI HFSEDLTLFD EMPLIPRTLL NEDQTCVELI RLRIPSVVIL DDETEAQLPE
     FLADIVQKLG GIVLKRLDTS IQHPLVKKYI HSPLPSAILQ IMEKIPLQKL CNQIASLLPT
     HKDALRKFLA SLTDTSEKEK RIIQELTIFK RINHSSDQGI SSYTKLKGCK VLDHTAKLPT
     DLRLSVSVID SSDEATIRLA NMLKIEKLKT TSCLKFVLKD IGNAFYTQEE VTQLMLWILE
     NLSSLKNENS NVLDWLMPLK FIHMSQGHVV AAGDLFDPDI EVLRDLFYNE EEACFPPTIF
     TSPDILHSLR QIGLKNESSL KEKDVVQVAR KIEALQVSSC QNQDVLMKKA KTLLLVLNKN
     QTLLQSSEGK MALKKIKWVP ACKERPPNYP GSLVWKGDLC NLCAPPDMCD AAHAVLVGSS
     LPLVESVHVN LEQALSIFTK PTINAVLKHF KTVVDWYTSK TFSDEDYYQF QHILLEIYGF
     MHDHLSEGKD SFKALKFPWV WTGKNFCPLA QAVIKPTHDL DLQPYLYNVP KTMAKFHQLF
     KACGSIEELT SDHISMVIQK VYLKSDQELS EEESKQNLHL MLNIMRWLYS NQIPASPNTP
     VPIYHSRNPS KLVMKPIHEC CYCDIKVDDL NDLLEDSVEP IILVHEDIPM KTAEWLKVPC
     LSTRLINPEN MGFEQSGQRE PLTVRIKNIL EEYPSVSDIF KELLQNADDA NATECSFMID
     MRRNMDIREN LLDPGMAACH GPALWSFNNS EFSDSDFLNI TRLGESLKRG EVDKVGKFGL
     GFNSVYHITD IPIIMSREFM IMFDPNINHI SKHIKDRSNP GIKINWSKQQ KRLRKFPNQF
     KPFIDVFGCQ LPLAVEAPYS YNGTLFRLSF RTQQEAKVSE VSSTCYNTAD IYSLVDEFSL
     CGHRLIIFTQ SVNSMYLKYL KIEETNPSLA QDTIIIKKKV CPSKALNAPV LSVLKEAAKL
     MKTCSSSNKK LPTDVPKSSC ILQITVEEFH HVFRRIADLQ SPLFRGPDDD PATLFEMAKS
     GQSKKPSDEL PQKTVDCTTW LICTCMDTGE ALKFSLNESG RRLGLVPCGA VGVLLHETQE
     QKWTVKPHIG EVFCYLPLRI KTGLPIHING CFAVTSNRKE IWKTDTKGRW NTTFMRHVIV
     KAYLQALSVL RDLAIGGELT DYTYYAVWPD PDLVHDDFSV ICKGFYEDIA HGKGKELTRV
     FSDGSMWVSM KNVRFLDDSI LQRKDVGSAA FKIFLKYLKK TGSKNLCAVE LPSSVKAGFE
     EAGCKQILLE NTFSEKQFFS EVFFPNIQEI EAELRDPLMN FVLNEKLDEF SGILRVTPCV
     PCSLEGHPLV LPSRLIHPEG RVAKLFDTKD GRFPYGSTQD YLNPIILIKL VQLGMAKDDI
     LWDDMLERAE SVAEINKSDH AAACLRSSIL LSLIDEKLKI KDPRAKDFAA KYQTIPFLPF
     LTKPAGFSLE WKGNSFKPET MFAATDIYTA EYQDIVCLLQ PILNENSHSF RGCGSVSLAV
     KEFLGLLKKP TVDLVINQLK QVAKSVDDGI TLYQENITNA CYKYLHEAVL QNEMAKATII
     EKLKPFCFIL VENVYVESEK VSFHLNFEAA PYLYQLPNKY KNNFRELFES VGVRQSFTVE
     DFALVLESID QERGKKQITE ENFQLCRRII SEGIWSLIRE KRQEFCEKNY GKILLPDTNL
     LLLPAKSLCY NDCPWIKVKD STVKYCHADI PREVAVKLGA IPKRHKALER YASNICFTAL
     GTEFGQKEKL TSRIKSILNA YPSEKEMLKE LLQNADDAKA TEICFVFDPR QHPVDRIFDD
     KWAPLQGPAL CVYNNQPFTE DDVRGIQNLG KGTKEGNPCK TGHYGIGFNS VYHITDCPSF
     ISGNDILGIF DPHARYAPGA TSVSPGRMFR DLDADFRTQF SDVLDLYLGN HFKLDNCTMF
     RFPLRNAEMA QVSEISSVPS SDRMVQNLLD KLRSDGAELL MFLNHMEKIS ICEIDKATGG
     LNVLYSVKGK ITDGDRLKRK QFHASVIDSV TKKRQLKDIP VQQITYTMDT EDSEGNLTTW
     LICNRSGFSS MEKVSKSVIS AHKNQDITLF PRGGVAACIT HNYKKPHRAF CFLPLSLETG
     LPFHVNGHFA LDSARRNLWR DDNGVGVRSD WNNSLMTALI APAYVELLIQ LKKRYFPGSD
     PTLSVLQNTP IHVVKDTLKK FLSFFPVNRL DLQPDLYCLV KALYSCIHED MKRLLPVVRA
     PNIDGSDLHS AVIITWINMS TSNKTRPFFD NLLQDELQHL KNADYNITTR KTVAENVYRL
     KHLLLEIGFN LVYNCDETAN LYHCLVDADI PVSYVTPADV RSFLMTFSSP DTNCHIGKLP
     CRLQQTNLKL FHSLKLLVDY CFKDAEESEF EVEGLPLLIT LDSVLQIFDG KRPKFLTTYH
     ELIPSRKDLF MNTLYLKYSS VLLNCKVAKV FDISSFADLL SSVLPREYKT KNCAKWKDNF
     ASESWLKNAW HFISESVSVT DDQEEPKPAF DVIVDILKDW ALLPGTKFTV STSQLVVPEG
     DVLIPLSLMH IAVFPNAQSD KVFHALMKAG CIQLALNKIC SKDSALVPLL SCHTANIDSP
     ASILKAVHYM VQTSTFRTEK LMENDFEALL MYFNCNLSHL MSQDDIKILK SLPCYKSISG
     RYMSIAKFGT CYVLTKSIPS AEVEKWTQSS SSAFLEEKVH LKELYEVLGC VPVDDLEVYL
     KHLLPKIENL SYDAKLEHLI YLKNRLASIE EPSEIKEQLF EKLESLLIIH DANNRLKQAK
     HFYDRTVRVF EVMLPEKLFI PKEFFKKLEQ VIKPKNQAAF MTSWVEFLRN IGLKYALSQQ
     QLLQFAKEIS VRANTENWSK ETLQSTVDIL LHHIFQERMD LLSGNFLKEL SLIPFLCPER
     APAEYIRFHP QYQEVNGTLP LIKFNGAQVN PKFKQCDVLQ LLWTSCPILP EKATPLSIKE
     QEGSDLAPQE QLEQVLNMLN VNLDPPLDKV INNCRNICNI TTLDEEMVKT RAKVLRSIYE
     FLSAEKREFR FQLRGVAFVM VEDGWKLLKP EEVVINLEYE ADFKPYLYKL PLELGTFHQL
     FKHLGTEDII STKQYVEVLS RIFKSSEGKQ LDPNEMRTVK RVVSGLFKSL QNDSVKVRSD
     LENARDLALY LPSQDGKLVK SSILVFDDAP HYKSRIQGNI GVQMLVDLSQ CYLGKDHGFH
     TKLIMLFPQK LRPRLLSSIL EEQLDEETPK VCQFGALCSL QGRLQLLLSS EQFITGLIRI
     MKHENDNAFL ANEEKAIRLC KALREGLKVS CFEKLQTTLR VKGFNPIPHS RSETFAFLKR
     FGNAVILLYI QHSDSKDINF LLALAMTLKS ATDNLISDTS YLIAMLGCND IYRISEKLDS
     LGVKYDSSEP SKLELPMPGT PIPAEIHYTL LMDPMNVFYP GEYVGYLVDA EGGDIYGSYQ
     PTYTYAIIVQ EVEREDADNT SFLGKIYQID IGYSEYKIVS SLDLYKFSRP DESSQNRDSA
     PTTPTSPTEF LTPGLRSIPP LFSGKESHKS PSTKHHSPRK LKVNALPEIL KEVTSVVEQA
     WKLPESERKK IIRRLYLKWH PDKNPENHDI ANEVFKHLQN EINRLEKQAF LDQNADRASR
     RTFSTSASRF QSDKYSFQRF YTSWNQEATS HKSERQQQSK EKCPPSAGQT YSQRFFVPPT
     FKSVGNPVEA RRWLRQARAN FSAARNDLHK NANEWVCFKC YLSTKLALIA ADYAVRGKSD
     KDVKPTALAQ KIEEYSQQLE GLTNDVHTLE AYGVDSLKTR YPDLLPFPQI PNDRFTSEVA
     MRVMECTACI IIKLENFIQQ KV
 
 
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