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SADH_MYCTO
ID   SADH_MYCTO              Reviewed;         276 AA.
AC   P9WGP8; F2GNY3; L0TEA6; O53302; Q7D656;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Putative oxidoreductase SadH;
DE            EC=1.-.-.-;
GN   Name=sadH; OrderedLocusNames=MT3170;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for maintaining the appropriate mycolic acid
CC       composition and permeability of the envelope on its exposure to acidic
CC       pH. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47506.1; -; Genomic_DNA.
DR   PIR; A70853; A70853.
DR   RefSeq; WP_003416074.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGP8; -.
DR   SMR; P9WGP8; -.
DR   EnsemblBacteria; AAK47506; AAK47506; MT3170.
DR   KEGG; mtc:MT3170; -.
DR   PATRIC; fig|83331.31.peg.3416; -.
DR   HOGENOM; CLU_010194_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..276
FT                   /note="Putative oxidoreductase SadH"
FT                   /id="PRO_0000428324"
FT   ACT_SITE        155
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         142
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   276 AA;  29217 MW;  4721366EEBE3E270 CRC64;
     MSSFEGKVAV ITGAGSGIGR ALALNLSEKR AKLALSDVDT DGLAKTVRLA QALGAQVKSD
     RLDVAEREAV LAHADAVVAH FGTVHQVYNN AGIAYNGNVD KSEFKDIERI IDVDFWGVVN
     GTKAFLPHVI ASGDGHIVNI SSLFGLIAVP GQSAYNAAKF AVRGFTEALR QEMLVARHPV
     KVTCVHPGGI KTAVARNATV ADGEDQQTFA EFFDRRLALH SPEMAAKTIV NGVAKGQARV
     VVGLEAKAVD VLARIMGSSY QRLVAAGVAK FFPWAK
 
 
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