ID   SAER_STAA3              Reviewed;         228 AA.
AC   Q2FIT4;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Response regulator SaeR;
DE   AltName: Full=Staphylococcus exoprotein expression protein R;
GN   Name=saeR; OrderedLocusNames=SAUSA300_0691;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Member of the two-component regulatory system SaeR/SaeS
CC       involved in the regulation of staphylococcal virulence factors in a
CC       strain-dependent fashion. Probably functions as a transcriptional
CC       regulator via a specific DNA-binding domain, recognizing motifs near
CC       the promoter sequences of target genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by SaeS. {ECO:0000250}.
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DR   EMBL; CP000255; ABD22784.1; -; Genomic_DNA.
DR   RefSeq; WP_000149344.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FIT4; -.
DR   SMR; Q2FIT4; -.
DR   EnsemblBacteria; ABD22784; ABD22784; SAUSA300_0691.
DR   KEGG; saa:SAUSA300_0691; -.
DR   HOGENOM; CLU_000445_30_4_9; -.
DR   OMA; IMITARV; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Sensory transduction;
KW   Transcription; Transcription regulation; Two-component regulatory system;
KW   Virulence.
FT   CHAIN           1..228
FT                   /note="Response regulator SaeR"
FT                   /id="PRO_0000295926"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        127..226
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   228 AA;  26858 MW;  9364A49366DF1BA5 CRC64;
     MTHLLIVDDE QDIVDICQTY FEYEGYKVTT TTSGKEAISL LSNDIDIMVL DIMMPEVNGY
     DIVKEMKRQK LDIPFIYLTA KTQEHDTIYA LTLGADDYVK KPFSPRELVL RINNLLTRMK
     KYHHQPVEQL SFDELTLINL SKVVTVNGHE VPMRIKEFEL LWYLASRENE VISKSELLEK
     VWGYDYYEDA NTVNVHIHRI REKLEKESFT TYTITTVWGL GYKFERSR