ID   SAER_STAAM              Reviewed;         228 AA.
AC   Q99VR7;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Response regulator SaeR;
DE   AltName: Full=Staphylococcus exoprotein expression protein R;
GN   Name=saeR; OrderedLocusNames=SAV0706;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system SaeR/SaeS
CC       involved in the regulation of staphylococcal virulence factors in a
CC       strain-dependent fashion. Probably functions as a transcriptional
CC       regulator via a specific DNA-binding domain, recognizing motifs near
CC       the promoter sequences of target genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by SaeS. {ECO:0000250}.
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DR   EMBL; BA000017; BAB56868.1; -; Genomic_DNA.
DR   RefSeq; WP_000149344.1; NC_002758.2.
DR   AlphaFoldDB; Q99VR7; -.
DR   SMR; Q99VR7; -.
DR   World-2DPAGE; 0002:Q99VR7; -.
DR   PaxDb; Q99VR7; -.
DR   EnsemblBacteria; BAB56868; BAB56868; SAV0706.
DR   KEGG; sav:SAV0706; -.
DR   HOGENOM; CLU_000445_30_4_9; -.
DR   OMA; IMITARV; -.
DR   PhylomeDB; Q99VR7; -.
DR   BioCyc; SAUR158878:SAV_RS03875-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Sensory transduction;
KW   Transcription; Transcription regulation; Two-component regulatory system;
KW   Virulence.
FT   CHAIN           1..228
FT                   /note="Response regulator SaeR"
FT                   /id="PRO_0000295922"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        127..226
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   228 AA;  26858 MW;  9364A49366DF1BA5 CRC64;
     MTHLLIVDDE QDIVDICQTY FEYEGYKVTT TTSGKEAISL LSNDIDIMVL DIMMPEVNGY
     DIVKEMKRQK LDIPFIYLTA KTQEHDTIYA LTLGADDYVK KPFSPRELVL RINNLLTRMK
     KYHHQPVEQL SFDELTLINL SKVVTVNGHE VPMRIKEFEL LWYLASRENE VISKSELLEK
     VWGYDYYEDA NTVNVHIHRI REKLEKESFT TYTITTVWGL GYKFERSR