SAER_STAEQ
ID SAER_STAEQ Reviewed; 229 AA.
AC Q5HR28;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Response regulator SaeR;
GN Name=saeR; OrderedLocusNames=SERP0365;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Member of the two-component regulatory system SaeR/SaeS.
CC Probably functions as a transcriptional regulator via a specific DNA-
CC binding domain, recognizing motifs near the promoter sequences of
CC target genes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated by SaeS. {ECO:0000250}.
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DR EMBL; CP000029; AAW53763.1; -; Genomic_DNA.
DR RefSeq; WP_001830352.1; NC_002976.3.
DR AlphaFoldDB; Q5HR28; -.
DR SMR; Q5HR28; -.
DR STRING; 176279.SERP0365; -.
DR EnsemblBacteria; AAW53763; AAW53763; SERP0365.
DR GeneID; 50019368; -.
DR KEGG; ser:SERP0365; -.
DR eggNOG; COG0745; Bacteria.
DR HOGENOM; CLU_000445_30_4_9; -.
DR OMA; IMITARV; -.
DR OrthoDB; 817710at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IDA:CACAO.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Sensory transduction; Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1..229
FT /note="Response regulator SaeR"
FT /id="PRO_0000295928"
FT DOMAIN 3..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 128..227
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 51
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 229 AA; 26833 MW; 9EB059C21CA0BB56 CRC64;
MTHLLIVDDE KDIVDICQTY FEYEGYQVTT TTCGKEALKL LSSDIDIMIL DIMMPEVSGY
DIVKKMKDMQ LDIPFIYLTA KTQEHDTIYA LTLGADDYIK KPFSPRELVL RTNNLLARMS
KSNHSNKIEQ LEFDGLVLKN LSKTLTINNI EIPMRIKEFE LLWYLASREG EVISKSELLE
KVWGYDYYED ANTVNVHIHR IREKLEKHDF LPYTITTVWG LGYKFERSR
