ID   SAER_STAES              Reviewed;         229 AA.
AC   Q8CQ17;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Response regulator SaeR;
GN   Name=saeR; OrderedLocusNames=SE_0479;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Member of the two-component regulatory system SaeR/SaeS.
CC       Probably functions as a transcriptional regulator via a specific DNA-
CC       binding domain, recognizing motifs near the promoter sequences of
CC       target genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by SaeS. {ECO:0000250}.
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DR   EMBL; AE015929; AAO04076.1; -; Genomic_DNA.
DR   RefSeq; NP_764034.1; NC_004461.1.
DR   RefSeq; WP_001830352.1; NZ_WBME01000018.1.
DR   PDB; 4IXA; X-ray; 2.15 A; A/B=128-229.
DR   PDBsum; 4IXA; -.
DR   AlphaFoldDB; Q8CQ17; -.
DR   SMR; Q8CQ17; -.
DR   STRING; 176280.SE_0479; -.
DR   EnsemblBacteria; AAO04076; AAO04076; SE_0479.
DR   GeneID; 50019368; -.
DR   KEGG; sep:SE_0479; -.
DR   PATRIC; fig|176280.10.peg.451; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_9; -.
DR   OMA; IMITARV; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA-binding; Phosphoprotein; Sensory transduction;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..229
FT                   /note="Response regulator SaeR"
FT                   /id="PRO_0000295927"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        128..227
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   STRAND          130..133
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   STRAND          136..139
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   TURN            140..143
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   STRAND          144..147
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   STRAND          150..152
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   HELIX           156..166
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   TURN            167..170
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   HELIX           175..182
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   STRAND          183..186
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   HELIX           193..207
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   STRAND          212..218
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   TURN            219..221
FT                   /evidence="ECO:0007829|PDB:4IXA"
FT   STRAND          222..227
FT                   /evidence="ECO:0007829|PDB:4IXA"
SQ   SEQUENCE   229 AA;  26833 MW;  9EB059C21CA0BB56 CRC64;
     MTHLLIVDDE KDIVDICQTY FEYEGYQVTT TTCGKEALKL LSSDIDIMIL DIMMPEVSGY
     DIVKKMKDMQ LDIPFIYLTA KTQEHDTIYA LTLGADDYIK KPFSPRELVL RTNNLLARMS
     KSNHSNKIEQ LEFDGLVLKN LSKTLTINNI EIPMRIKEFE LLWYLASREG EVISKSELLE
     KVWGYDYYED ANTVNVHIHR IREKLEKHDF LPYTITTVWG LGYKFERSR