ID   SAFA_SHISS              Reviewed;          65 AA.
AC   Q3Z1P4;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Two-component-system connector protein SafA;
GN   Name=safA; OrderedLocusNames=SSON_1623;
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ss046;
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA   Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA   Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA   Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT   bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Connects the signal transduction between the two-component
CC       systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and
CC       thus activating the PhoQ/PhoP system, in response to acid stress
CC       conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PhoQ. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       type II membrane protein {ECO:0000250}.
CC   -!- INDUCTION: By acid stress, via the EvgS/EvgA system. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SafA family. {ECO:0000305}.
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DR   EMBL; CP000038; AAZ88318.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3Z1P4; -.
DR   SMR; Q3Z1P4; -.
DR   EnsemblBacteria; AAZ88318; AAZ88318; SSON_1623.
DR   KEGG; ssn:SSON_1623; -.
DR   HOGENOM; CLU_2842804_0_0_6; -.
DR   OMA; NYKGIMS; -.
DR   Proteomes; UP000002529; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031411; SafA.
DR   Pfam; PF17073; SafA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal-anchor;
KW   Stress response; Transmembrane; Transmembrane helix.
FT   CHAIN           1..65
FT                   /note="Two-component-system connector protein SafA"
FT                   /id="PRO_0000223721"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        19..39
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..65
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   65 AA;  7354 MW;  088CCB00FC85A7EF CRC64;
     MYATTVKNKI TQRDNYKEIM SVIVVVLLLT LTLIAIFSAI DQLGISEMGR IARDLTHFII
     NSLQD