ID   ABCH2_DICDI             Reviewed;         513 AA.
AC   Q8T664; Q55FI8;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=ABC transporter H family member 2;
GN   Name=abcH2; ORFNames=DDB_G0267428;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC   STRAIN=AX4;
RX   PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA   Anjard C., Loomis W.F.;
RT   "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL   Eukaryot. Cell 1:643-652(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AF482961; AAL96259.1; -; Genomic_DNA.
DR   EMBL; AAFI02000003; EAL73166.1; -; Genomic_DNA.
DR   RefSeq; XP_647545.1; XM_642453.1.
DR   AlphaFoldDB; Q8T664; -.
DR   SMR; Q8T664; -.
DR   STRING; 44689.DDB0191241; -.
DR   PaxDb; Q8T664; -.
DR   EnsemblProtists; EAL73166; EAL73166; DDB_G0267428.
DR   GeneID; 8616352; -.
DR   KEGG; ddi:DDB_G0267428; -.
DR   dictyBase; DDB_G0267428; abcH2.
DR   eggNOG; KOG0055; Eukaryota.
DR   HOGENOM; CLU_531496_0_0_1; -.
DR   InParanoid; Q8T664; -.
DR   OMA; EFICIFG; -.
DR   PhylomeDB; Q8T664; -.
DR   PRO; PR:Q8T664; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IGC:dictyBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IGC:dictyBase.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IGC:dictyBase.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Transport.
FT   CHAIN           1..513
FT                   /note="ABC transporter H family member 2"
FT                   /id="PRO_0000346861"
FT   DOMAIN          39..280
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          291..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..313
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..471
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         75..82
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   513 AA;  57536 MW;  16352F6711CBE581 CRC64;
     MAQVFPDVIE EKIQDDDKFF GQTRLKNDDI DFNDPDNVLT MKNIHKTYLL GIEGVPALRG
     VSMAIKRGEF ICIFGTSGGG KTTMLNIIGT IDKPTKGEMK LCGKTINHKT TDKDLAFLRL
     RNIGFVFQTF NLLSSLTALE NVEMPMILLG ELSASERRER AISLLTKVGM KDRLDHFPSQ
     LSGGEQQRVT IARAIANNPD VLLLDEPTGD LDTVNTSVIM KLLTDLNKQE NITLIMVTHD
     VGLKMYSDRI IWMRDGKIQR IETVQEQSKR EHYQKLYKEC ELINQNQKNG VTSVFKNDDD
     NKNIKKQGTL TEFRRPTDYK SIASYNNNNS NLNNNSNSNS NNNSNNNNSK NYASSSSSSS
     VLNGKLSQST VNNSSIYNHN NDSPFFNSNN NNNINNNINN NNNNNNNNNN NNNNNNNNNN
     NNNNNNNNSN SNNNNSNSNN NNNNTKSNNN NNNNIFDIAS SSSSYSNNNN NSKNNSLIDD
     IYLDINEGSS SNFSNNDNFK SVDQITNDLS RIL