ABCH4_DICDI
ID ABCH4_DICDI Reviewed; 882 AA.
AC Q54QY9;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=ABC transporter H family member 4;
DE AltName: Full=ABC transporter ABCH.4;
GN Name=abcH4; ORFNames=DDB_G0283479;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCH family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000055; EAL65724.1; -; Genomic_DNA.
DR RefSeq; XP_639102.1; XM_634010.1.
DR AlphaFoldDB; Q54QY9; -.
DR STRING; 44689.DDB0220442; -.
DR PaxDb; Q54QY9; -.
DR PRIDE; Q54QY9; -.
DR EnsemblProtists; EAL65724; EAL65724; DDB_G0283479.
DR GeneID; 8624126; -.
DR KEGG; ddi:DDB_G0283479; -.
DR dictyBase; DDB_G0283479; abcH4.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_326652_0_0_1; -.
DR InParanoid; Q54QY9; -.
DR OMA; DNIRVGN; -.
DR PRO; PR:Q54QY9; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..882
FT /note="ABC transporter H family member 4"
FT /id="PRO_0000391606"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 384..863
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 522..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 418..425
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 882 AA; 100176 MW; 8912B8794407B64B CRC64;
MKNWIKLKLT AIGWFIYGMP ISVFYRYLWL RNKTLLFKTI AVHYIIPLII ELLPWYASKR
KIGNYLRTSR VEITHTMSTN GPYSHSAVIK YVLLTIYYAI LDNINSHLIS IVSLENRLQI
RRLVMEKLLY SEIGAFDFLR KKKNIGPAEL EYKLSSSINT TISFFTYTIP DLIASIYAFV
IEGSELLKKG HKIDPLIVLH PILIAIYQKV SQKLRERLVE NNPDSSKFKD PYNSAMSKMI
SNTAEGLSDI QINNLQETQL GLFDNLIEKE LSNTQSFSTL ISRTWRSIHN RSLFEFAAEV
WVAHKVMDRQ KIDNQLYRTT LLDINRVIRL GNRLFQSLGS FKNIYKHQKK VKKLLNIPTF
IEEDSHLKYI YKFEELKVSS DLKFSYENKF SSELPSFPVL DLQNEMVILP NKRYALIGQN
RSGKSTLNHL LCKLYTPTEG QISMNGIPYS EISRSSIRRM ISYVSQRPFI FPGTIMDNIR
VGNPSATEEQ VLEAADAAGV FAFADDNNFS LKQSFDSLSD TFDPDMEIPP TISPLSTSSN
NINNTTTTTT NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NKNNNNNNNK
PTTPTFVPSS PSQYSTINKS TIINNNTFIR RNSSMSQLNN SGGGNVNGNN NNNNNNNNNN
NININNSGVG GRRNSVMDLQ NKLLNQCDES ESNKLVKRVW SVLNLTSISN SGGGDESDDD
DEEAERNQRS LTPIIVPQLI DGGLSNHPIL NQVVEAGGKN ISGGFAQSIA LARIFVRTEA
KIVILDESMS QMDAFKKREI IFPKLFGFAE KHNITLIIVT HDLASVQNTV DHIFVLDHGK
LCHQGSHEEL MNENAQVYYK LLGLRKRFKN QSFNNLNTNT NK
