ID   SAHH_STRFR              Reviewed;         120 AA.
AC   P26799;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Adenosylhomocysteinase;
DE            EC=3.3.1.1;
DE   AltName: Full=S-adenosyl-L-homocysteine hydrolase;
DE            Short=AdoHcyase;
DE   Flags: Fragment;
GN   Name=ahcY;
OS   Streptomyces fradiae (Streptomyces roseoflavus).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1906;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14544 / DSM 40758 / IMRU 3739 / NCIMB 11726 / NRRL B-2841;
RX   PubMed=1614864; DOI=10.1093/nar/20.11.2767;
RA   Romero N.M., Parro V., Malpartida F., Mellado R.P.;
RT   "Heterologous activation of the actinorhodin biosynthetic pathway in
RT   Streptomyces lividans.";
RL   Nucleic Acids Res. 20:2767-2772(1992).
CC   -!- FUNCTION: May play a key role in the regulation of the intracellular
CC       concentration of adenosylhomocysteine. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine;
CC         Xref=Rhea:RHEA:21708, ChEBI:CHEBI:15377, ChEBI:CHEBI:16335,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:58199; EC=3.3.1.1;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC       Note=Binds 1 NAD(+) per subunit. {ECO:0000250};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-
CC       homocysteine from S-adenosyl-L-homocysteine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC       {ECO:0000305}.
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DR   EMBL; X64391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S22958; S22958.
DR   AlphaFoldDB; P26799; -.
DR   SMR; P26799; -.
DR   STRING; 1906.SFRA_32965; -.
DR   eggNOG; COG0499; Bacteria.
DR   UniPathway; UPA00314; UER00076.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004013; F:adenosylhomocysteinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1480; -; 1.
DR   InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR   InterPro; IPR000043; Adenosylhomocysteinase-like.
DR   InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23420; PTHR23420; 1.
DR   Pfam; PF05221; AdoHcyase; 1.
DR   Pfam; PF00670; AdoHcyase_NAD; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
FT   CHAIN           <1..120
FT                   /note="Adenosylhomocysteinase"
FT                   /id="PRO_0000116991"
FT   BINDING         34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   120 AA;  13559 MW;  9A65BC41A711EE70 CRC64;
     IPGIVKDEVK PQVHTWTFAD GKKIIVLSEG RLLNLGNATG HPSFVMSNSF ADQTLAQIEL
     YTKPEQYPTD VYVLPKHLDE KVARLHLDAL GVKLTTLRPE QAEYIGVEVE GPYKPDHYRY