ID   SAK_BPPHD               Reviewed;         163 AA.
AC   Q8SDJ8;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   23-FEB-2022, entry version 62.
DE   RecName: Full=Staphylokinase;
DE   Flags: Precursor;
GN   Name=sak;
OS   Staphylococcus phage phi13 (Bacteriophage phi-13).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Bronfenbrennervirinae; Peeveelvirus.
OX   NCBI_TaxID=186153;
OH   NCBI_TaxID=286; Pseudomonas.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12036589; DOI=10.1016/s0378-1119(02)00481-x;
RA   Iandolo J.J., Worrell V., Groicher K.H., Qian Y., Tian R., Kenton S.,
RA   Dorman A., Ji H., Lin S., Loh P., Qi S., Zhu H., Roe B.A.;
RT   "Comparative analysis of the genomes of the temperate bacteriophages phi
RT   11, phi 12 and phi 13 of Staphylococcus aureus 8325.";
RL   Gene 289:109-118(2002).
CC   -!- FUNCTION: Potent plasminogen activator that converts plasminogen into
CC       plasmin. It forms a 1:1 complex with plasmin, which in turn activates
CC       other plasminogen molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the staphylokinase family. {ECO:0000305}.
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DR   EMBL; AF424783; AAL82378.1; -; Genomic_DNA.
DR   RefSeq; NP_803403.1; NC_004617.1.
DR   SMR; Q8SDJ8; -.
DR   GeneID; 1258157; -.
DR   KEGG; vg:1258157; -.
DR   Proteomes; UP000002099; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031639; P:plasminogen activation; IEA:InterPro.
DR   InterPro; IPR004093; SAK.
DR   InterPro; IPR036120; SAK/SK_sf.
DR   Pfam; PF02821; Staphylokinase; 1.
DR   SUPFAM; SSF54328; SSF54328; 1.
PE   3: Inferred from homology;
KW   Plasminogen activation; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..163
FT                   /note="Staphylokinase"
FT                   /id="PRO_0000031606"
SQ   SEQUENCE   163 AA;  18504 MW;  E56D9FF5187DE141 CRC64;
     MLKRSLLFLT VLLLLFSFSS ITNEVSASSS FDKGKYKKGD DASYFEPTGP YLMVNVTGVD
     GKGNELLSPH YVEFPIKPGT TLTKEKIEYY VEWALDATAY KEFRVVELDP SAKIEVTYYD
     KNKKKEETKS FPITEKGFVV PDLSEHIKNP GFNLITKVII EKK