SAK_STAAR
ID SAK_STAAR Reviewed; 163 AA.
AC Q6GFB2;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Staphylokinase;
DE Flags: Precursor;
GN Name=sak; OrderedLocusNames=SAR2039;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Potent plasminogen activator that converts plasminogen into
CC plasmin. It forms a 1:1 complex with plasmin, which in turn activates
CC other plasminogen molecules (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the staphylokinase family. {ECO:0000305}.
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DR EMBL; BX571856; CAG41024.1; -; Genomic_DNA.
DR RefSeq; WP_000919350.1; NC_002952.2.
DR AlphaFoldDB; Q6GFB2; -.
DR BMRB; Q6GFB2; -.
DR SMR; Q6GFB2; -.
DR KEGG; sar:SAR2039; -.
DR HOGENOM; CLU_137975_0_0_9; -.
DR OrthoDB; 1446265at2; -.
DR PRO; PR:Q6GFB2; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031639; P:plasminogen activation; IEA:InterPro.
DR InterPro; IPR004093; SAK.
DR InterPro; IPR036120; SAK/SK_sf.
DR Pfam; PF02821; Staphylokinase; 1.
DR SUPFAM; SSF54328; SSF54328; 1.
PE 3: Inferred from homology;
KW Plasminogen activation; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000250"
FT CHAIN 28..163
FT /note="Staphylokinase"
FT /id="PRO_0000031601"
SQ SEQUENCE 163 AA; 18474 MW; 3DB45E35046029DD CRC64;
MLKRGLLFLT VLLLLFSFSS ITNEVSASSS FDKGKYKKGD DASYFEPTGP YLMVNVTGVD
GKGNELLSPH YVEFPIKPGT TLTKEKIEYY VEWALDATAY KEFRVVELDP SAKIEVTYYD
KNKKKEETKS FPITEKGFVV PDLSEHIKNP GFNLITKVII EKK