ID   SAK_STAAS               Reviewed;         163 AA.
AC   Q6G7Z1;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Staphylokinase;
DE   Flags: Precursor;
GN   Name=sak; OrderedLocusNames=SAS1868;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Potent plasminogen activator that converts plasminogen into
CC       plasmin. It forms a 1:1 complex with plasmin, which in turn activates
CC       other plasminogen molecules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the staphylokinase family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG43674.1; -; Genomic_DNA.
DR   RefSeq; WP_000920038.1; NC_002953.3.
DR   AlphaFoldDB; Q6G7Z1; -.
DR   BMRB; Q6G7Z1; -.
DR   SMR; Q6G7Z1; -.
DR   KEGG; sas:SAS1868; -.
DR   HOGENOM; CLU_137975_0_0_9; -.
DR   PRO; PR:Q6G7Z1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031639; P:plasminogen activation; IEA:InterPro.
DR   InterPro; IPR004093; SAK.
DR   InterPro; IPR036120; SAK/SK_sf.
DR   Pfam; PF02821; Staphylokinase; 1.
DR   SUPFAM; SSF54328; SSF54328; 1.
PE   3: Inferred from homology;
KW   Plasminogen activation; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..163
FT                   /note="Staphylokinase"
FT                   /id="PRO_0000031602"
SQ   SEQUENCE   163 AA;  18490 MW;  E56D9FF50AEDE141 CRC64;
     MLKRSLLFLT VLLLLFSFSS ITNEVSASSS FDKGKYKKGD DASYFEPTGP YLMVNVTGVD
     GKGNELLSPH YVEFPIKPGT TLTKEKIEYY VEWALDATAY KEFRVVELDP SAKIEVTYYD
     KNKKKEETKS FPITEKGFVV PDLSEHIKNP GFNLITKVVI EKK