ID   SALA_DROSI              Reviewed;         139 AA.
AC   P21749;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Protein spalt-accessory;
DE   Flags: Precursor;
GN   Name=sala; Synonyms=sal;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2568636; DOI=10.1073/pnas.86.14.5483;
RA   Reuter D., Schuh R., Jaeckle H.;
RT   "The homeotic gene spalt (sal) evolved during Drosophila speciation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5483-5486(1989).
CC   -!- FUNCTION: Likely to be involved in the establishment of the head.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M21227; AAA28877.1; -; Genomic_DNA.
DR   PIR; B33910; B33910.
DR   AlphaFoldDB; P21749; -.
DR   ChiTaRS; sls; fly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Developmental protein; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..139
FT                   /note="Protein spalt-accessory"
FT                   /id="PRO_0000022269"
FT   REGION          60..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..139
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   139 AA;  14145 MW;  AED5D51561C229CF CRC64;
     MKLLIALLAL VTAAIAQNGF GQGGYGGQGG FGGFGGLGGQ AGFGGQIGFN GQGGVGGQVG
     IGQGGVHPGQ GGFAGQGSPN QYQPGYGNPV GSGHFHGGNP VESGHFHGNP HEYPEHHGEH
     HREHHEHHGH HEHHGHHRH