ID   SALK5_KALTU             Reviewed;         151 AA.
AC   E2D0Z0;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Pollen allergen Sal k 5.0101 {ECO:0000305};
DE   AltName: Full=Allergen Sal k 5 {ECO:0000303|PubMed:24356442};
DE   AltName: Full=Olee1-like protein Sal k 5 {ECO:0000303|PubMed:24356442};
DE   AltName: Allergen=Sal k 5.0101 {ECO:0000305};
DE   Flags: Fragment;
OS   Kali turgidum (Prickly saltwort) (Salsola kali).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Chenopodiaceae; Salsoloideae; Salsoleae; Kali.
OX   NCBI_TaxID=151250 {ECO:0000312|EMBL:ADK22842.1};
RN   [1] {ECO:0000312|EMBL:ADK22842.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-3; 15-21; 30-42; 67-82
RP   AND 118-125, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, MASS
RP   SPECTROMETRY, ALLERGEN, AND CIRCULAR DICHROISM ANALYSIS.
RC   TISSUE=Pollen {ECO:0000303|PubMed:24356442, ECO:0000312|EMBL:ADK22842.1};
RX   PubMed=24356442; DOI=10.1159/000356345;
RA   Castro L., Mas S., Barderas R., Colas C., Garcia-Selles J., Barber D.,
RA   Rodriguez R., Villalba M.;
RT   "Sal k 5, a member of the widespread Ole e 1-like protein family, is a new
RT   allergen of Russian thistle (Salsola kali) pollen.";
RL   Int. Arch. Allergy Immunol. 163:142-153(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24356442}.
CC   -!- TISSUE SPECIFICITY: Expressed in pollen (at protein level).
CC       {ECO:0000269|PubMed:24356442}.
CC   -!- PTM: N-glycosylated. Contains fucose monosaccharides in the glycan
CC       structure. {ECO:0000269|PubMed:24356442}.
CC   -!- MASS SPECTROMETRY: Mass=17628; Method=MALDI; Note=The measured mass is
CC       that of the mature protein.; Evidence={ECO:0000269|PubMed:24356442};
CC   -!- ALLERGEN: Causes an allergic reaction in human. Natural protein binds
CC       to IgE in 32% and 40% of the 57 S.kali pollen-allergic patients tested
CC       from the center (Zaragoza) and east coast (Murcia) of Spain,
CC       respectively. IgE-binding is decreased when the disulfide bonds are
CC       disrupted. {ECO:0000269|PubMed:24356442}.
CC   -!- SIMILARITY: Belongs to the Ole e I family. {ECO:0000305}.
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DR   EMBL; GQ427676; ADK22842.1; -; mRNA.
DR   AlphaFoldDB; E2D0Z0; -.
DR   SMR; E2D0Z0; -.
DR   Allergome; 8202; Sal k 5.
DR   Allergome; 8203; Sal k 5.0101.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006041; Pollen_Ole_e1_allergen.
DR   PANTHER; PTHR31614; PTHR31614; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Secreted.
FT   CHAIN           <1..151
FT                   /note="Pollen allergen Sal k 5.0101"
FT                   /id="PRO_0000449241"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   DISULFID        17..88
FT                   /evidence="ECO:0000250|UniProtKB:P19963"
FT   DISULFID        20..132
FT                   /evidence="ECO:0000250|UniProtKB:P19963"
FT   DISULFID        41..76
FT                   /evidence="ECO:0000250|UniProtKB:P19963"
FT   CONFLICT        3
FT                   /note="K -> N (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        39..40
FT                   /note="LQ -> IK (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        75
FT                   /note="I -> L (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        77..78
FT                   /note="QI -> KL (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:ADK22842.1"
SQ   SEQUENCE   151 AA;  16449 MW;  F8AC0EB7449BF16B CRC64;
     KGKGGHNLYH VKGMVYCDTC RIQFITRVST MMEGATVSLQ CRNLTAGTET FKAEAVTDKL
     GMYTIKVDGD HEDDICQIVL VKSPGQECSE IPNDVYSEQA AKVTLTSNNG EASDVRNANA
     LGFLKKAPLP ECPEVLKELD MYDVPGSVTQ N