SALL_METJA
ID SALL_METJA Reviewed; 263 AA.
AC Q59045;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Chlorinase MJ1651;
DE EC=2.5.1.-;
GN OrderedLocusNames=MJ1651;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 2-261, AND SUBUNIT.
RX PubMed=17910070; DOI=10.1002/prot.21646;
RA Rao K.N., Burley S.K., Swaminathan S.;
RT "Crystal structure of a conserved protein of unknown function (MJ1651) from
RT Methanococcus jannaschii.";
RL Proteins 70:572-577(2008).
CC -!- SUBUNIT: Homotrimer. {ECO:0000269|PubMed:17910070}.
CC -!- SIMILARITY: Belongs to the SAM hydrolase / SAM-dependent halogenase
CC family. {ECO:0000305}.
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DR EMBL; L77117; AAB99672.1; -; Genomic_DNA.
DR PIR; A64506; A64506.
DR PDB; 2F4N; X-ray; 2.50 A; A/B/C=2-261.
DR PDBsum; 2F4N; -.
DR AlphaFoldDB; Q59045; -.
DR SMR; Q59045; -.
DR STRING; 243232.MJ_1651; -.
DR PRIDE; Q59045; -.
DR EnsemblBacteria; AAB99672; AAB99672; MJ_1651.
DR KEGG; mja:MJ_1651; -.
DR eggNOG; arCOG04309; Archaea.
DR HOGENOM; CLU_059734_1_1_2; -.
DR InParanoid; Q59045; -.
DR OMA; EGYVGAM; -.
DR PhylomeDB; Q59045; -.
DR EvolutionaryTrace; Q59045; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.90; -; 1.
DR Gene3D; 3.40.50.10790; -; 1.
DR InterPro; IPR002747; SAM_Chlor/Fluor.
DR InterPro; IPR023227; SAM_OH_AdoTrfase_C.
DR InterPro; IPR023228; SAM_OH_AdoTrfase_N.
DR PANTHER; PTHR35092; PTHR35092; 1.
DR Pfam; PF01887; SAM_adeno_trans; 1.
DR PIRSF; PIRSF006779; UCP006779; 1.
DR SUPFAM; SSF101852; SSF101852; 1.
DR SUPFAM; SSF102522; SSF102522; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Transferase.
FT CHAIN 1..263
FT /note="Chlorinase MJ1651"
FT /id="PRO_0000107459"
FT BINDING 18
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 80..82
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 135..138
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 138
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /evidence="ECO:0000250"
FT STRAND 12..18
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 21..24
FT /evidence="ECO:0007829|PDB:2F4N"
FT HELIX 25..38
FT /evidence="ECO:0007829|PDB:2F4N"
FT TURN 39..41
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 45..51
FT /evidence="ECO:0007829|PDB:2F4N"
FT HELIX 58..68
FT /evidence="ECO:0007829|PDB:2F4N"
FT HELIX 69..71
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 76..80
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 91..96
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 101..108
FT /evidence="ECO:0007829|PDB:2F4N"
FT HELIX 111..117
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 119..124
FT /evidence="ECO:0007829|PDB:2F4N"
FT HELIX 139..152
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 172..176
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 178..180
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 182..185
FT /evidence="ECO:0007829|PDB:2F4N"
FT HELIX 188..190
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 199..204
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 206..208
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 210..217
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 219..222
FT /evidence="ECO:0007829|PDB:2F4N"
FT TURN 223..226
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 229..232
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 238..241
FT /evidence="ECO:0007829|PDB:2F4N"
FT HELIX 247..251
FT /evidence="ECO:0007829|PDB:2F4N"
FT STRAND 258..261
FT /evidence="ECO:0007829|PDB:2F4N"
SQ SEQUENCE 263 AA; 30249 MW; 801E2C3E5A66CDD0 CRC64;
MGIYMRDDIL DIITLTTDFG TNEGYVGAMK GRILNILKKY NKDAKIIDIS HEIKPFNIYH
GAYVLLTAIP YFPPSVHVAV IDPTVGSERK SIVIETKSGY YLVGPDNGLF TYVAEKLGIK
RIIKIDEERY KPSSTFHGRD VYAVVGAEIL INNGYDGEEL DEMVKIDETK KRVIHIDRFG
NIITNIKKDE VTFKYYDTIM IKIRHKNGIE KIIKCKFVKS YFEEKNNFIC LINSEGFLEI
SKFMDNASKL LNVDYLDEIE IIY
