SALM_DROME
ID SALM_DROME Reviewed; 1365 AA.
AC P39770; Q8MSC6; Q9VKH2;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 3.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Homeotic protein spalt-major;
GN Name=salm; Synonyms=sal; ORFNames=CG6464;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=7905822; DOI=10.1002/j.1460-2075.1994.tb06246.x;
RA Kuehnlein R.P., Frommer G., Friedrich M., Gonzalez-Gaitan M., Weber A.,
RA Wagner-Bernholz J.F., Gehring W.J., Jaeckle H., Schuh R.;
RT "Spalt encodes an evolutionarily conserved zinc finger protein of novel
RT structure which provides homeotic gene function in the head and tail region
RT of the Drosophila embryo.";
RL EMBO J. 13:168-179(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 855-1365.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739; SER-744; SER-1076 AND
RP SER-1079, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Required for the establishment of the posterior-most head and
CC the anterior-most tail segments of the embryo. Probably function as a
CC transcriptional regulator. Could repress the transcription of the tsh
CC gene. {ECO:0000269|PubMed:7905822}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: First expressed at blastoderm stage and later in
CC restricted aeras of the embryonic nervous system as well as in the
CC developing trachea. {ECO:0000269|PubMed:7905822}.
CC -!- SIMILARITY: Belongs to the sal C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM50766.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA53229.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X75541; CAA53229.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE014134; AAF53097.3; -; Genomic_DNA.
DR EMBL; AY118906; AAM50766.1; ALT_INIT; mRNA.
DR PIR; S40022; S40022.
DR RefSeq; NP_723670.2; NM_164966.3.
DR AlphaFoldDB; P39770; -.
DR SMR; P39770; -.
DR BioGRID; 60626; 27.
DR IntAct; P39770; 11.
DR STRING; 7227.FBpp0088852; -.
DR iPTMnet; P39770; -.
DR PaxDb; P39770; -.
DR PRIDE; P39770; -.
DR EnsemblMetazoa; FBtr0089913; FBpp0088852; FBgn0261648.
DR GeneID; 34569; -.
DR KEGG; dme:Dmel_CG6464; -.
DR CTD; 34569; -.
DR FlyBase; FBgn0261648; salm.
DR VEuPathDB; VectorBase:FBgn0261648; -.
DR eggNOG; KOG1074; Eukaryota.
DR GeneTree; ENSGT00940000167374; -.
DR InParanoid; P39770; -.
DR OMA; KEEDHRT; -.
DR OrthoDB; 244207at2759; -.
DR PhylomeDB; P39770; -.
DR SignaLink; P39770; -.
DR BioGRID-ORCS; 34569; 0 hits in 3 CRISPR screens.
DR ChiTaRS; sls; fly.
DR GenomeRNAi; 34569; -.
DR PRO; PR:P39770; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0261648; Expressed in wing disc and 48 other tissues.
DR ExpressionAtlas; P39770; baseline and differential.
DR Genevisible; P39770; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048098; P:antennal joint development; IMP:FlyBase.
DR GO; GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:FlyBase.
DR GO; GO:0021782; P:glial cell development; IMP:FlyBase.
DR GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; TAS:FlyBase.
DR GO; GO:0030539; P:male genitalia development; IMP:FlyBase.
DR GO; GO:0008584; P:male gonad development; IMP:FlyBase.
DR GO; GO:0048644; P:muscle organ morphogenesis; IMP:FlyBase.
DR GO; GO:0035155; P:negative regulation of terminal cell fate specification, open tracheal system; IMP:FlyBase.
DR GO; GO:0035310; P:notum cell fate specification; IMP:FlyBase.
DR GO; GO:0007438; P:oenocyte development; IMP:FlyBase.
DR GO; GO:0007424; P:open tracheal system development; IMP:FlyBase.
DR GO; GO:0045466; P:R7 cell differentiation; IMP:FlyBase.
DR GO; GO:0045465; P:R8 cell differentiation; IMP:FlyBase.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:FlyBase.
DR GO; GO:0042659; P:regulation of cell fate specification; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:FlyBase.
DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR GO; GO:0007525; P:somatic muscle development; IMP:FlyBase.
DR GO; GO:0035277; P:spiracle morphogenesis, open tracheal system; IMP:FlyBase.
DR GO; GO:0035202; P:tracheal pit formation in open tracheal system; IMP:FlyBase.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..1365
FT /note="Homeotic protein spalt-major"
FT /id="PRO_0000047018"
FT ZN_FING 451..473
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 479..501
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 824..846
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 852..874
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 884..906
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1289..1311
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1317..1339
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 47..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..298
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..552
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1079
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 739
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 744
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1076
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1079
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 178
FT /note="K -> M (in Ref. 1; CAA53229)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="P -> T (in Ref. 1; CAA53229)"
FT /evidence="ECO:0000305"
FT CONFLICT 1142
FT /note="P -> K (in Ref. 1; CAA53229)"
FT /evidence="ECO:0000305"
FT CONFLICT 1180
FT /note="H -> D (in Ref. 1; CAA53229)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1365 AA; 150319 MW; BDF5896C43CD016A CRC64;
MKNHLSNVLC AMRSDFKDNH QETINKMIQF GTVKYGIVKQ LKDRARSADK DIGSDQEENG
GCSPLTTATT TASPSRSPEP EEEQPEEQST SEQSIPEQST PDHQLENDIK SEAKSEIEPV
EDNNNRVAMT KPSSEEREPN ASGSMPSSPV AEASAEEAAT ERTPEKEKEK DVEVDVEKPD
EAPSSAVPST EVTLPGGAGA PVTLEAIQNM QMAIAQFAAK TIANGSNGAD NEAAMKQLAF
LQQTLFNLQQ QQLFQIQLIQ QLQSQLALNQ AKQEEDTEED ADQEQDQEQE TDTYEEEERI
ADMELRQKAE ARMAEAKARQ HLINAGVPLR ESSGSPAESL KRRREHDHES QPNRRPSLDN
THKADTAQDA LAKLKEMENT PLPFGSDLAS SIITNHDDLP EPNSLDLLQK RAQEVLDSAS
QGILANSMAD DFAFGEKSGE GKGRNEPFFK HRCRYCGKVF GSDSALQIHI RSHTGERPFK
CNVCGSRFTT KGNLKVHFQR HAQKFPHVPM NATPIPEHMD KFHPPLLDQM SPTDSSPNHS
PAPPPLGSAP ASFPPAFPGL QNLYRPPMEI LKSLGAAAPH QYFPQELPTD LRKPSPQLDE
DEPQVKNEPV EEKDQREEHE QEMAECSEPE PEPLPLEVRI KEERVEEQEQ VKQEDHRIEP
RRTPSPSSEH RSPHHHRHSH MGYPPVVQPI QPAALMHPQS SPGSQSHLDH LPTPGQLPPR
EDFFAERFPL NFTTAKMLSP EHHSPVRSPA GGALPPGVPP PPHHHPHHMA RSPFFNPIKH
EMAALLPRPH SNDNSWENFI EVSNTCETMK LKELMKNKKI SDPNQCVVCD RVLSCKSALQ
MHYRTHTGER PFKCRICGRA FTTKGNLKTH MAVHKIRPPM RNFHQCPVCH KKYSNALVLQ
QHIRLHTGEP TDLTPEQIQA AEIRDPPPSM MPGHFMNPFA AAAFHFGALP GGPGGPPGPN
HGAHNGALGS ESSQGDMDDN MDCGEDYDDD VSSEHLSNSN LEQEGDRSRS GDDFKSLLFE
QKLRIDATGV VNTNPVRPRS SASSHGHSVG STSAPTSPSV HASSQVIKRS SSPARSEASQ
GALDLTPRAA PTSSSSSRSP LPKEKPVSPP SLPRSPSGSS HASANILTSP LPPTVGIDCL
PPGLQHHLQQ QHQHLMQQQA AVAAAAAAQH HHHQQMAALH QHQEQLRREA AEAQQKAAAA
AAAAAAAAAA QRQTPPQARD QRQEGGPGAG PPPNPLMGAR PPFGMFPNLP LFPPATTQNM
CNAMNQIAQS VMPAAPFNPL ALSGVRGSTT CGICYKTFPC HSALEIHYRS HTKERPFKCS
ICDRGFTTKG NLKQHMLTHK IRDMEQETFR NRAVKYMSEW NEDRE
