ID   SAM10_HUMAN             Reviewed;         202 AA.
AC   Q9BYL1;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Sterile alpha motif domain-containing protein 10;
DE            Short=SAM domain-containing protein 10;
GN   Name=SAMD10; Synonyms=C20orf136;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AL118506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC067362; AAH67362.1; -; mRNA.
DR   CCDS; CCDS13549.1; -.
DR   RefSeq; NP_542188.1; NM_080621.4.
DR   RefSeq; XP_016883160.1; XM_017027671.1.
DR   AlphaFoldDB; Q9BYL1; -.
DR   SMR; Q9BYL1; -.
DR   BioGRID; 126661; 11.
DR   STRING; 9606.ENSP00000358902; -.
DR   iPTMnet; Q9BYL1; -.
DR   PhosphoSitePlus; Q9BYL1; -.
DR   BioMuta; SAMD10; -.
DR   DMDM; 26392486; -.
DR   MassIVE; Q9BYL1; -.
DR   PaxDb; Q9BYL1; -.
DR   PeptideAtlas; Q9BYL1; -.
DR   PRIDE; Q9BYL1; -.
DR   ProteomicsDB; 79666; -.
DR   Antibodypedia; 48062; 29 antibodies from 12 providers.
DR   DNASU; 140700; -.
DR   Ensembl; ENST00000369886.8; ENSP00000358902.3; ENSG00000130590.14.
DR   GeneID; 140700; -.
DR   KEGG; hsa:140700; -.
DR   MANE-Select; ENST00000369886.8; ENSP00000358902.3; NM_080621.5; NP_542188.1.
DR   UCSC; uc002yhm.2; human.
DR   CTD; 140700; -.
DR   GeneCards; SAMD10; -.
DR   HGNC; HGNC:16129; SAMD10.
DR   HPA; ENSG00000130590; Low tissue specificity.
DR   neXtProt; NX_Q9BYL1; -.
DR   OpenTargets; ENSG00000130590; -.
DR   PharmGKB; PA25678; -.
DR   VEuPathDB; HostDB:ENSG00000130590; -.
DR   eggNOG; ENOG502QWNA; Eukaryota.
DR   GeneTree; ENSGT00390000008161; -.
DR   HOGENOM; CLU_105476_1_0_1; -.
DR   InParanoid; Q9BYL1; -.
DR   OMA; HCGLYHT; -.
DR   OrthoDB; 1252828at2759; -.
DR   PhylomeDB; Q9BYL1; -.
DR   TreeFam; TF325918; -.
DR   PathwayCommons; Q9BYL1; -.
DR   SignaLink; Q9BYL1; -.
DR   BioGRID-ORCS; 140700; 22 hits in 1078 CRISPR screens.
DR   ChiTaRS; SAMD10; human.
DR   GenomeRNAi; 140700; -.
DR   Pharos; Q9BYL1; Tdark.
DR   PRO; PR:Q9BYL1; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q9BYL1; protein.
DR   Bgee; ENSG00000130590; Expressed in right hemisphere of cerebellum and 113 other tissues.
DR   ExpressionAtlas; Q9BYL1; baseline and differential.
DR   Genevisible; Q9BYL1; HS.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd09510; SAM_aveugle-like; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR039144; Aveugle-like_SAM_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..202
FT                   /note="Sterile alpha motif domain-containing protein 10"
FT                   /id="PRO_0000097568"
FT   DOMAIN          118..184
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
SQ   SEQUENCE   202 AA;  22770 MW;  DF2678F090A3E946 CRC64;
     MFTELRSKLS PPRGRAGAVR AGFGERRDVD ATAHFSFCRT LLEHTVSAES IPCHLPRTPG
     TSLTWHDSRS QRAASSRPIK LLQQPGTDTP QGRLYSDHYG LYHTSPSLGG LTRPVVLWSQ
     QDVCKWLKKH CPHNYLVYVE AFSQHAITGR ALLRLNAEKL QRMGLAQEAQ RQEVLQQVLR
     LQVREEGRSL QLLSQASFGK MS