SAM14_HUMAN
ID SAM14_HUMAN Reviewed; 417 AA.
AC Q8IZD0; A5D8V1; Q8N2X0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Sterile alpha motif domain-containing protein 14;
DE Short=SAM domain-containing protein 14;
GN Name=SAMD14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Guo J.H., Yu L.;
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IZD0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IZD0-2; Sequence=VSP_020659;
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DR EMBL; AY148482; AAN71008.1; -; mRNA.
DR EMBL; AK094209; BAG52844.1; -; mRNA.
DR EMBL; CH471109; EAW94641.1; -; Genomic_DNA.
DR EMBL; BC029872; AAH29872.1; -; mRNA.
DR EMBL; BC136485; AAI36486.1; -; mRNA.
DR EMBL; BC141822; AAI41823.1; -; mRNA.
DR EMBL; BC142728; AAI42729.1; -; mRNA.
DR CCDS; CCDS11560.1; -. [Q8IZD0-2]
DR CCDS; CCDS58562.1; -. [Q8IZD0-1]
DR RefSeq; NP_001244288.1; NM_001257359.1. [Q8IZD0-1]
DR RefSeq; NP_777580.1; NM_174920.3. [Q8IZD0-2]
DR RefSeq; XP_016879812.1; XM_017024323.1. [Q8IZD0-1]
DR RefSeq; XP_016879813.1; XM_017024324.1. [Q8IZD0-2]
DR AlphaFoldDB; Q8IZD0; -.
DR SMR; Q8IZD0; -.
DR IntAct; Q8IZD0; 1.
DR STRING; 9606.ENSP00000424474; -.
DR iPTMnet; Q8IZD0; -.
DR PhosphoSitePlus; Q8IZD0; -.
DR BioMuta; SAMD14; -.
DR DMDM; 115502829; -.
DR MassIVE; Q8IZD0; -.
DR PeptideAtlas; Q8IZD0; -.
DR PRIDE; Q8IZD0; -.
DR ProteomicsDB; 71320; -. [Q8IZD0-1]
DR ProteomicsDB; 71321; -. [Q8IZD0-2]
DR Antibodypedia; 30475; 65 antibodies from 17 providers.
DR DNASU; 201191; -.
DR Ensembl; ENST00000330175.9; ENSP00000329144.4; ENSG00000167100.15. [Q8IZD0-1]
DR Ensembl; ENST00000503131.1; ENSP00000424474.1; ENSG00000167100.15. [Q8IZD0-2]
DR GeneID; 201191; -.
DR KEGG; hsa:201191; -.
DR MANE-Select; ENST00000330175.9; ENSP00000329144.4; NM_001257359.2; NP_001244288.1.
DR UCSC; uc002iqf.5; human. [Q8IZD0-1]
DR CTD; 201191; -.
DR DisGeNET; 201191; -.
DR GeneCards; SAMD14; -.
DR HGNC; HGNC:27312; SAMD14.
DR HPA; ENSG00000167100; Tissue enhanced (brain).
DR MIM; 619233; gene.
DR neXtProt; NX_Q8IZD0; -.
DR OpenTargets; ENSG00000167100; -.
DR PharmGKB; PA142670953; -.
DR VEuPathDB; HostDB:ENSG00000167100; -.
DR eggNOG; KOG1945; Eukaryota.
DR GeneTree; ENSGT00940000160279; -.
DR HOGENOM; CLU_054578_0_0_1; -.
DR InParanoid; Q8IZD0; -.
DR OMA; PSPRTRY; -.
DR OrthoDB; 1276206at2759; -.
DR PhylomeDB; Q8IZD0; -.
DR TreeFam; TF331870; -.
DR PathwayCommons; Q8IZD0; -.
DR SignaLink; Q8IZD0; -.
DR BioGRID-ORCS; 201191; 11 hits in 1070 CRISPR screens.
DR ChiTaRS; SAMD14; human.
DR GenomeRNAi; 201191; -.
DR Pharos; Q8IZD0; Tbio.
DR PRO; PR:Q8IZD0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8IZD0; protein.
DR Bgee; ENSG00000167100; Expressed in right hemisphere of cerebellum and 153 other tissues.
DR ExpressionAtlas; Q8IZD0; baseline and differential.
DR Genevisible; Q8IZD0; HS.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR043446; Neurabin-like.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR16154; PTHR16154; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..417
FT /note="Sterile alpha motif domain-containing protein 14"
FT /id="PRO_0000250563"
FT DOMAIN 326..389
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 37..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 377..417
FT /evidence="ECO:0000255"
FT COMPBIAS 155..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K070"
FT MOD_RES 108
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K070"
FT MOD_RES 173
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K070"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BJU3"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K070"
FT MOD_RES 283
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8K070"
FT VAR_SEQ 274
FT /note="Q -> QAQLLAHAQEALSNSWCLVQDFGSTQIGM (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_020659"
SQ SEQUENCE 417 AA; 45056 MW; AC180362D67F4400 CRC64;
MASSKLREPV DEVFDLDLAV PETARLDSSL HKARAQLLAK GRRHRPSRSR LRDSASSAED
GEGSDGPGGK VTDGCGSPLH RLRSPLHSGP GSPAGGSFCL DPPGLRRSLD EDEPPPSPLT
RYRPLHNAAS HEGLAAASCS PPRSAPSSDS SPSFVRRHPR AEPHSEDDSR DASPPEPASP
TIGLDKKTRR KFLDLGVTLR RASTGKSRKE KGSNRLSMGS RESVEGSGRS GGSPFLPFSW
FTDSGKGSAS SGSTTSPTCS PKHEGFSPKK SASQESTLSD DSTPPSSSPK IPSGPWQEAK
CSYPYHTLSQ SSDEFLDEPL PPVHHWTSQQ VGQWLQSLNL EQYAAEFAAR QVDGPQLLQL
DGSKLKSLGL SNSHDRALVK RKLKEMAAAA EKERKAQEKA ARQREKLRRR EQEAKKS
