ID   SAM14_RAT               Reviewed;         417 AA.
AC   Q5BJU3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Sterile alpha motif domain-containing protein 14;
DE            Short=SAM domain-containing protein 14;
GN   Name=Samd14;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108; SER-173 AND SER-179, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC091329; AAH91329.1; -; mRNA.
DR   RefSeq; NP_001020137.1; NM_001024966.1.
DR   AlphaFoldDB; Q5BJU3; -.
DR   SMR; Q5BJU3; -.
DR   BioGRID; 252269; 1.
DR   STRING; 10116.ENSRNOP00000005519; -.
DR   iPTMnet; Q5BJU3; -.
DR   PhosphoSitePlus; Q5BJU3; -.
DR   PaxDb; Q5BJU3; -.
DR   GeneID; 287637; -.
DR   KEGG; rno:287637; -.
DR   UCSC; RGD:1306138; rat.
DR   CTD; 201191; -.
DR   RGD; 1306138; Samd14.
DR   eggNOG; KOG1945; Eukaryota.
DR   InParanoid; Q5BJU3; -.
DR   OrthoDB; 1276206at2759; -.
DR   PhylomeDB; Q5BJU3; -.
DR   PRO; PR:Q5BJU3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR043446; Neurabin-like.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR16154; PTHR16154; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..417
FT                   /note="Sterile alpha motif domain-containing protein 14"
FT                   /id="PRO_0000250565"
FT   DOMAIN          326..389
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          37..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          375..416
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        140..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..262
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         84
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K070"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         173
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         179
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         279
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K070"
FT   MOD_RES         283
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K070"
SQ   SEQUENCE   417 AA;  45196 MW;  2422E24B10DEAE08 CRC64;
     MASSKLREPV DEVFDLDLAV PETTRLDSSL HKARAQLLVK GRRHRPSRSR LRDSTSSAED
     GEGSDGPGGK VTDGCGSPLH RLRSPLHSGP GSPAGGSFCL EPPGLRRSLD EDEPPPSPLA
     RYRPLHNAAS HEGLAATSGS PPRSAPSSDS SPSFVRRYPR AEPHSEDDSR DASPPEPASP
     TIGLDKKTRR KFLDLGVTLR RASTSKSRKE KGSNRLSMGS RESVEGSGRT GGSPFLPFSW
     FTDSGKGSAS SGSTTSPTCS PKHEGFSPKK SASQESTLSD DSTPPSSSPK IPGDPRQETK
     CSYPYHTLSQ SSDEFLDESL PAVEHWTSQQ VGQWLHSLNL EQYAAEFAAR QVDGPQLLQL
     DGSKLKSLGL SNSHDRALVK RKLKELAAAA EKERKAQEKT ARQREKLRRR EHEAKKS