SAM15_HUMAN
ID SAM15_HUMAN Reviewed; 674 AA.
AC Q9P1V8; Q2M3P3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Sterile alpha motif domain-containing protein 15;
DE Short=SAM domain-containing protein 15;
GN Name=SAMD15; Synonyms=C14orf174, FAM15A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9P1V8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P1V8-2; Sequence=VSP_023431, VSP_023432;
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DR EMBL; AC007954; AAF62561.1; -; Genomic_DNA.
DR EMBL; BC104834; AAI04835.1; -; mRNA.
DR EMBL; BC104836; AAI04837.1; -; mRNA.
DR CCDS; CCDS32126.1; -. [Q9P1V8-1]
DR RefSeq; NP_001010860.1; NM_001010860.1. [Q9P1V8-1]
DR AlphaFoldDB; Q9P1V8; -.
DR SMR; Q9P1V8; -.
DR BioGRID; 127788; 4.
DR STRING; 9606.ENSP00000216471; -.
DR iPTMnet; Q9P1V8; -.
DR PhosphoSitePlus; Q9P1V8; -.
DR BioMuta; SAMD15; -.
DR DMDM; 74753112; -.
DR MassIVE; Q9P1V8; -.
DR PaxDb; Q9P1V8; -.
DR PeptideAtlas; Q9P1V8; -.
DR PRIDE; Q9P1V8; -.
DR ProteomicsDB; 83669; -. [Q9P1V8-1]
DR ProteomicsDB; 83670; -. [Q9P1V8-2]
DR Antibodypedia; 26042; 54 antibodies from 14 providers.
DR DNASU; 161394; -.
DR Ensembl; ENST00000216471.5; ENSP00000216471.4; ENSG00000100583.5. [Q9P1V8-1]
DR GeneID; 161394; -.
DR KEGG; hsa:161394; -.
DR MANE-Select; ENST00000216471.5; ENSP00000216471.4; NM_001010860.4; NP_001010860.1.
DR UCSC; uc001xtq.2; human. [Q9P1V8-1]
DR CTD; 161394; -.
DR DisGeNET; 161394; -.
DR GeneCards; SAMD15; -.
DR HGNC; HGNC:18631; SAMD15.
DR HPA; ENSG00000100583; Tissue enhanced (retina, testis).
DR neXtProt; NX_Q9P1V8; -.
DR OpenTargets; ENSG00000100583; -.
DR PharmGKB; PA134903169; -.
DR VEuPathDB; HostDB:ENSG00000100583; -.
DR eggNOG; ENOG502S3Z4; Eukaryota.
DR GeneTree; ENSGT00630000089942; -.
DR HOGENOM; CLU_028120_0_0_1; -.
DR InParanoid; Q9P1V8; -.
DR OMA; MGEFFKD; -.
DR OrthoDB; 532179at2759; -.
DR PhylomeDB; Q9P1V8; -.
DR TreeFam; TF351017; -.
DR PathwayCommons; Q9P1V8; -.
DR BioGRID-ORCS; 161394; 11 hits in 1068 CRISPR screens.
DR GenomeRNAi; 161394; -.
DR Pharos; Q9P1V8; Tdark.
DR PRO; PR:Q9P1V8; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9P1V8; protein.
DR Bgee; ENSG00000100583; Expressed in sperm and 123 other tissues.
DR ExpressionAtlas; Q9P1V8; baseline and differential.
DR Genevisible; Q9P1V8; HS.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR042554; SAMD15.
DR PANTHER; PTHR46829; PTHR46829; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..674
FT /note="Sterile alpha motif domain-containing protein 15"
FT /id="PRO_0000279427"
FT DOMAIN 545..608
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 1..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 564..570
FT /note="ECFITNF -> VYKNKMF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023431"
FT VAR_SEQ 571..674
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023432"
FT VARIANT 18
FT /note="L -> P (in dbSNP:rs11844594)"
FT /id="VAR_030890"
FT VARIANT 168
FT /note="M -> I (in dbSNP:rs45527334)"
FT /id="VAR_061613"
FT VARIANT 370
FT /note="K -> E (in dbSNP:rs4903576)"
FT /id="VAR_030891"
FT VARIANT 454
FT /note="K -> E (in dbSNP:rs2193595)"
FT /id="VAR_030892"
SQ SEQUENCE 674 AA; 77151 MW; 21F439D7A43AA59E CRC64;
MAEVPEDYDS GPDEDGELEP ERPELPGLHK LYENAEPDTM AKADSKLPAE IYQEPQPETE
EEDFKEGEPD SAKNVQLKPG GTSQEGIAKE SKRDVPSETE PGIHQEVKSE TSREMGEFFK
DLEAPMDETH KESDLEPPEE AKPNVTEDVF LESAMETDPD PVPPTETMSE VSGATVRERN
LELLEEETEP GVPEESLRVQ HEETGLEPPE QTKQDFPSEK LGESLEETDL QPPKMTKPET
PEETQRESTE KKRTEPPEQA RLEFLEKEPR KSSEEAGLEP PEETQPEVPE EMQRKATEEK
GTELPERTKP DFPDHKPRKS TDENVPEPLE EIKLEFPEEE SRKTNEETIL EQSEMMKPES
PEEIRKSNEK KNPQPPEETG PVLPQEINPQ VEEKTQTKPT EKILELPDET KPRETHVEFS
KEDRPEPIKS KYSVGNDELE HREPKRGKLS LSDKFRKEYY ALGSLRESEE SIGTHYEFLQ
PLQKLLNVSE ECSYSDPSES QTELSEFVHE KEVVDLSQEL KERVSEDDET QPEKGTELQF
EHLNWDPEEV AEWISQLGFP QYKECFITNF ISGRKLIHVN CSNLPQMGIT NFEDMKAISR
HTQELLEIEE PLFKRSISLP YRDIIGLYLE QKGHTGIKSD SLTLSEFVKA AGLQDYAPEI
TAPEENEELP CTEP
