ID   SAM15_MACFA             Reviewed;         667 AA.
AC   Q95JY5; Q95JL7;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Sterile alpha motif domain-containing protein 15;
DE            Short=SAM domain-containing protein 15;
GN   Name=SAMD15; ORFNames=QtsA-12354, QtsA-15642;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q95JY5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q95JY5-2; Sequence=VSP_023433;
CC       Name=3;
CC         IsoId=Q95JY5-3; Sequence=VSP_023434;
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DR   EMBL; AB070042; BAB62987.1; -; mRNA.
DR   EMBL; AB070164; BAB63109.1; -; mRNA.
DR   RefSeq; NP_001306514.1; NM_001319585.1. [Q95JY5-2]
DR   AlphaFoldDB; Q95JY5; -.
DR   SMR; Q95JY5; -.
DR   STRING; 9541.XP_005561947.1; -.
DR   GeneID; 102137285; -.
DR   CTD; 161394; -.
DR   eggNOG; ENOG502S3Z4; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR042554; SAMD15.
DR   PANTHER; PTHR46829; PTHR46829; 2.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..667
FT                   /note="Sterile alpha motif domain-containing protein 15"
FT                   /id="PRO_0000279428"
FT   DOMAIN          538..601
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          1..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..270
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..424
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         129..172
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12498619"
FT                   /id="VSP_023433"
FT   VAR_SEQ         590..667
FT                   /note="AISRHTRELLEIEEPLFKRSISLPHRDIIGLYLEQKGHTGIKSDALTLSEFV
FT                   KAAGLQDYAPEITAPEENEELPCTEP -> TEVMDLGETSHRGDEPLPSHHIRKQFLDI
FT                   RGSSWKLKNHYSNAPSAFPIGILLACI (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:12498619"
FT                   /id="VSP_023434"
FT   CONFLICT        22
FT                   /note="R -> G (in Ref. 1; BAB62987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        51
FT                   /note="E -> G (in Ref. 1; BAB62987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        382
FT                   /note="R -> Q (in Ref. 1; BAB62987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        506
FT                   /note="V -> A (in Ref. 1; BAB62987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        557
FT                   /note="G -> E (in Ref. 1; BAB62987)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   667 AA;  76165 MW;  235E964BD878F293 CRC64;
     MAEVPEDYDS GPDEDGEPES ERPELHKSYE NAERDTMAEA DSKLPAEIYH EPQPETEEED
     FREGEPKSAK NVQLKPGGTA LEGIAKESKR DVPSETEPGI PQEVKSEREM GEFFKDLEAP
     MDETHESDLE PPEEAKLNVT EDVFLESAME TDPVPPTETM SEVSGATVRE RNLELLEEGT
     ELGVPEESLR VQHEETGVEP PEQTQLDFPS EKPGESLEET DLQPPKMTKP DIPEETQRES
     TEKKRTEPPE QARPEFPEKE PRKSSEEAGL EPPEETQPEV PGEMQRKATE EKGTELPERT
     KPDLPDHKSR KSTDENVPEP LEEIKLEFPE EESRKPNEET ILEQSEMMKP ESPEEIRKSN
     EEKNPQPPEE TGLVLPQEIN PRVEEKTQTK PTEEKNLELP DETKPRETHV EFPKEDRPEP
     IKSKYSVGKN ELEFREPKKG KWSLSDEFKK EYYALGSIRE SEESIGTHYE FSQPLQKSFD
     VSEVCSYLDP SESLTELNEF VHEKEVVDLS QDLKELVSED DETQSKQGTE LQFEHLNWDP
     EKVAEWISQL GFPQYKGCFI TNFISGRKLI HVNCSNLPQM GITNFEDMKA ISRHTRELLE
     IEEPLFKRSI SLPHRDIIGL YLEQKGHTGI KSDALTLSEF VKAAGLQDYA PEITAPEENE
     ELPCTEP