SAM50_DROME
ID SAM50_DROME Reviewed; 443 AA.
AC Q9V784; Q8STA1;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=SAM50-like protein CG7639;
GN ORFNames=CG7639;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: May play a role in the maintenance of the structure of
CC mitochondrial cristae. {ECO:0000250|UniProtKB:Q9Y512}.
CC -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC organizing system (MICOS) complex (also known as MINOS or MitOS
CC complex). {ECO:0000250|UniProtKB:Q9Y512}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q9Y512}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- DOMAIN: Its C-terminal part seems to contain many membrane-spanning
CC sided beta-sheets, that have the potential to adopt a transmembrane
CC beta-barrel type structure. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SAM50/omp85 family. {ECO:0000305}.
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DR EMBL; AE013599; AAS64850.1; -; Genomic_DNA.
DR EMBL; AY071492; AAL49114.1; -; mRNA.
DR EMBL; AY094882; AAM11235.1; -; mRNA.
DR RefSeq; NP_995838.1; NM_206116.3.
DR AlphaFoldDB; Q9V784; -.
DR SMR; Q9V784; -.
DR BioGRID; 62416; 4.
DR IntAct; Q9V784; 2.
DR STRING; 7227.FBpp0086555; -.
DR TCDB; 1.B.33.3.5; the outer membrane protein insertion porin (bam complex) (ompip) family.
DR PaxDb; Q9V784; -.
DR PRIDE; Q9V784; -.
DR DNASU; 36675; -.
DR EnsemblMetazoa; FBtr0087424; FBpp0086555; FBgn0033989.
DR GeneID; 36675; -.
DR KEGG; dme:Dmel_CG7639; -.
DR UCSC; CG7639-RB; d. melanogaster.
DR FlyBase; FBgn0033989; CG7639.
DR VEuPathDB; VectorBase:FBgn0033989; -.
DR eggNOG; KOG2602; Eukaryota.
DR GeneTree; ENSGT00390000011355; -.
DR HOGENOM; CLU_014798_3_0_1; -.
DR InParanoid; Q9V784; -.
DR OMA; REHCGPK; -.
DR OrthoDB; 844748at2759; -.
DR PhylomeDB; Q9V784; -.
DR BioGRID-ORCS; 36675; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36675; -.
DR PRO; PR:Q9V784; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033989; Expressed in adult hindgut (Drosophila) and 38 other tissues.
DR ExpressionAtlas; Q9V784; baseline and differential.
DR Genevisible; Q9V784; DM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IBA:GO_Central.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IBA:GO_Central.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR039910; D15-like.
DR InterPro; IPR034746; POTRA.
DR PANTHER; PTHR12815; PTHR12815; 1.
DR Pfam; PF01103; Omp85; 1.
DR PROSITE; PS51779; POTRA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Transmembrane; Transmembrane beta strand.
FT CHAIN 1..443
FT /note="SAM50-like protein CG7639"
FT /id="PRO_0000215941"
FT DOMAIN 23..101
FT /note="POTRA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ SEQUENCE 443 AA; 49059 MW; 9B0AEE0289A71FE0 CRC64;
MPKSGRDGGA SKDSKYDLSK ISARVDRVNV SGLLRTHNDY VMRAADGLFK ASNFQDLMLE
AMSTKSYLHE LGIFKDVSVH IDVSRGADAS PQGYEVTFKG NEMSRMMGSA GTEIGQNEGS
LRTELTIPNI LGRGENISLQ GSYSSTRAND LQLKFWKPFF HTRFKENRPE MSFSIFRQTD
RFDISSFQTT NIGYLVDFSA HTMVGVDLTH SLQYENAIRD VGLLNKSVPF AIRDHCGPKL
ASLLRYSVVY DNRDGNVFPT RGIYLKSVNE YCGLGGNVAY TSSTAHGELN VPLFAGLVAQ
FCARVGVVKE TKNTTQLPIS SLFYCGGPLT LRGFKFGGAG PVVESTPIGA QSFWCTGAHL
WAPLPFAGVF KNLASHFRMH FFYNIGNNNS FSTENMRSAF GMGLAVKLAE RARIELNYCV
PVRHQDTDRI LNGFQFGIGY EFV
