ID   SAM5A_DANRE             Reviewed;         469 AA.
AC   Q803G5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Sorting and assembly machinery component 50 homolog A;
GN   Name=samm50a; Synonyms=samm50; ORFNames=zgc:55803;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the maintenance of the structure of
CC       mitochondrial cristae. {ECO:0000250|UniProtKB:Q9Y512}.
CC   -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex (also known as MINOS or MitOS
CC       complex). {ECO:0000250|UniProtKB:Q9Y512}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q9Y512}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- DOMAIN: Its C-terminal part seems to contain many membrane-spanning
CC       sided beta-sheets, that have the potential to adopt a transmembrane
CC       beta-barrel type structure. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAM50/omp85 family. {ECO:0000305}.
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DR   EMBL; BC044493; AAH44493.1; -; mRNA.
DR   RefSeq; NP_956436.1; NM_200142.1.
DR   AlphaFoldDB; Q803G5; -.
DR   SMR; Q803G5; -.
DR   STRING; 7955.ENSDARP00000095193; -.
DR   PaxDb; Q803G5; -.
DR   GeneID; 393111; -.
DR   KEGG; dre:393111; -.
DR   CTD; 25813; -.
DR   ZFIN; ZDB-GENE-040426-806; samm50.
DR   eggNOG; KOG2602; Eukaryota.
DR   InParanoid; Q803G5; -.
DR   OrthoDB; 844748at2759; -.
DR   PhylomeDB; Q803G5; -.
DR   Reactome; R-DRE-9013404; RAC2 GTPase cycle.
DR   PRO; PR:Q803G5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR   GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR   GO; GO:0001889; P:liver development; IMP:ZFIN.
DR   GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IBA:GO_Central.
DR   GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IBA:GO_Central.
DR   InterPro; IPR000184; Bac_surfAg_D15.
DR   InterPro; IPR039910; D15-like.
DR   InterPro; IPR034746; POTRA.
DR   PANTHER; PTHR12815; PTHR12815; 1.
DR   Pfam; PF01103; Omp85; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane beta strand.
FT   CHAIN           1..469
FT                   /note="Sorting and assembly machinery component 50 homolog
FT                   A"
FT                   /id="PRO_0000383681"
FT   DOMAIN          45..125
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  52089 MW;  80EE6349A1157C4A CRC64;
     MGTVHARSLD PLPMQGPELG VQADDMDLGE PEREEKQEVL ENKDVVVQHV HIDGLGRTKE
     DILTYEIADV FHAKNLIDVM KKSHEARQKL LRLGIFRHVE VVIDTAEGAD ALPNGLDVTF
     EVRELRRMTG SYNTMVGNNE GSMVLGIKLP NVLGRAEKLT FQFSYGTKET SYGLSFFKPQ
     PGHFERNFSL NLYKVTGQFP WSSLRETDRG VSAEISFPIW RTSHTLKWEG VWRELGCLAR
     TASFAVREES GHSLKSSLAH AMVIDTRNST ILPRKGALLK INQELAGYTG GDVSFLKEDF
     EIQLNKTLFW DSVLSTSLWG GMLLPLGEKA SSIADRFYLG GPTSVRGFSM YSIGPQSEGD
     YLGGEAYWAG GVHLYTPLPF RPGRGGFGDL FRTHFFLNAG NLCNLNYGEG PRAHLSKLAE
     CIRWSYGAGI VLRLGNIARL ELNYCIPMGV QSGDRICDGV QFGAGIRFL