ID   SAM5B_DANRE             Reviewed;         469 AA.
AC   Q5U3I0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Sorting and assembly machinery component 50 homolog B;
GN   Name=samm50b; Synonyms=samm50l; ORFNames=zgc:103504;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the maintenance of the structure of
CC       mitochondrial cristae. {ECO:0000250|UniProtKB:Q9Y512}.
CC   -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex (also known as MINOS or MitOS
CC       complex). {ECO:0000250|UniProtKB:Q9Y512}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q9Y512}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- DOMAIN: Its C-terminal part seems to contain many membrane-spanning
CC       sided beta-sheets, that have the potential to adopt a transmembrane
CC       beta-barrel type structure. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAM50/omp85 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC085536; AAH85536.1; -; mRNA.
DR   RefSeq; NP_001007344.1; NM_001007343.1.
DR   AlphaFoldDB; Q5U3I0; -.
DR   SMR; Q5U3I0; -.
DR   STRING; 7955.ENSDARP00000058006; -.
DR   PaxDb; Q5U3I0; -.
DR   GeneID; 492471; -.
DR   KEGG; dre:492471; -.
DR   CTD; 492471; -.
DR   ZFIN; ZDB-GENE-041114-30; samm50l.
DR   eggNOG; KOG2602; Eukaryota.
DR   InParanoid; Q5U3I0; -.
DR   OrthoDB; 844748at2759; -.
DR   PhylomeDB; Q5U3I0; -.
DR   PRO; PR:Q5U3I0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR   GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR   GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IBA:GO_Central.
DR   GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IBA:GO_Central.
DR   InterPro; IPR000184; Bac_surfAg_D15.
DR   InterPro; IPR039910; D15-like.
DR   InterPro; IPR034746; POTRA.
DR   PANTHER; PTHR12815; PTHR12815; 1.
DR   Pfam; PF01103; Omp85; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane beta strand.
FT   CHAIN           1..469
FT                   /note="Sorting and assembly machinery component 50 homolog
FT                   B"
FT                   /id="PRO_0000383682"
FT   DOMAIN          45..125
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ   SEQUENCE   469 AA;  52184 MW;  7B10EEB1D9CB71CD CRC64;
     MGTVHARSMD SYPMYGRDLG VNTDDMEVME AVQETKQEVL ENKDVVVQHV NIEGLGRTKE
     DYLGYEISDV FTARNLVEVM RKSHEARQRL LRLGIFRDVE VVIDISEGAD ALPNGLDVTF
     EVTELKRLTG SYNTMVGNNE GSMVLGIKLP NMLGRGEKLT FQFSYGTKET SYGLSFFKPQ
     SGYFERNFTV NLYKVTGQFP WSSLKETDRG VSTELSLPLW MTDHTLKWEG VWRELGCLAR
     SASFAVREES GHTLKSALSH TMVVDTRNSA ILPRKGALLR INQELAGYTG GDANFLKEDV
     ELQLNKQFIW GSVLSASLWG GMIYPLGAQP TSIADRFYLG GPTSVRGFGM YSIGPQSEGD
     YLGGEAYWAG GLHLYTPLPF RSNKGGLADL FRTHFFLNAG NICNLNYGEG PRAHLQKLAE
     CIRWSYGAGI ILRLGNIARL ELNYCFPMGV QSGDRICDGV QFGAGIRFL