ID   SAM9L_MOUSE             Reviewed;        1561 AA.
AC   Q69Z37;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Sterile alpha motif domain-containing protein 9-like;
DE            Short=SAM domain-containing protein 9-like;
GN   Name=Samd9l; Synonyms=Kiaa2005;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart, Kidney, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24029230; DOI=10.1016/j.ccr.2013.08.011;
RA   Nagamachi A., Matsui H., Asou H., Ozaki Y., Aki D., Kanai A., Takubo K.,
RA   Suda T., Nakamura T., Wolff L., Honda H., Inaba T.;
RT   "Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes
RT   myeloid malignancies in mice mimicking human diseases with monosomy 7.";
RL   Cancer Cell 24:305-317(2013).
CC   -!- FUNCTION: May be involved in endosome fusion. Mediates down-regulation
CC       of growth factor signaling via internalization of growth factor
CC       receptors. {ECO:0000269|PubMed:24029230}.
CC   -!- SUBUNIT: Interacts with EEA1. {ECO:0000250|UniProtKB:Q8IVG5}.
CC   -!- INTERACTION:
CC       Q69Z37; Q15075: EEA1; Xeno; NbExp=2; IntAct=EBI-8784283, EBI-298113;
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:24029230}.
CC   -!- DISRUPTION PHENOTYPE: Mice die of white blood cells proliferation that
CC       accumulate in the bone marrow and interfere with the production of
CC       normal blood cells. {ECO:0000269|PubMed:24029230}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD32607.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK173329; BAD32607.1; ALT_INIT; Transcribed_RNA.
DR   AlphaFoldDB; Q69Z37; -.
DR   SMR; Q69Z37; -.
DR   IntAct; Q69Z37; 2.
DR   STRING; 10090.ENSMUSP00000112688; -.
DR   iPTMnet; Q69Z37; -.
DR   PhosphoSitePlus; Q69Z37; -.
DR   EPD; Q69Z37; -.
DR   jPOST; Q69Z37; -.
DR   MaxQB; Q69Z37; -.
DR   PaxDb; Q69Z37; -.
DR   PRIDE; Q69Z37; -.
DR   ProteomicsDB; 256588; -.
DR   MGI; MGI:1343184; Samd9l.
DR   eggNOG; ENOG502QPY6; Eukaryota.
DR   InParanoid; Q69Z37; -.
DR   ChiTaRS; Samd9l; mouse.
DR   PRO; PR:Q69Z37; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q69Z37; protein.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005769; C:early endosome; IDA:MGI.
DR   GO; GO:0035726; P:common myeloid progenitor cell proliferation; IMP:MGI.
DR   GO; GO:0034058; P:endosomal vesicle fusion; IMP:MGI.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IMP:MGI.
DR   GO; GO:0048536; P:spleen development; IMP:MGI.
DR   GO; GO:0017145; P:stem cell division; IMP:MGI.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Endosome; Reference proteome.
FT   CHAIN           1..1561
FT                   /note="Sterile alpha motif domain-containing protein 9-
FT                   like"
FT                   /id="PRO_0000279499"
FT   DOMAIN          14..79
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          78..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1561 AA;  180203 MW;  DC510ABEBDF226ED CRC64;
     MSGQVTQPKL IKDWTKEHVR KWVTEDLNIV EKYAQILFKE EVTGMVLQEL TEEDLREMGL
     PRGPALLIKR MYNKLISSPE SHNQDSRELN DKKLSTKEQQ TKTKNEEENS VSSNSDHGLR
     ETGQNEEQEP SLTKENMLGD VVTKDMEDNK PKPEQMSCTP YPFDSFCDVK QYIEHSILRV
     AETGPLNLID PIHEFKAFTN TKKATEEDIK MKFSNETFRF AAACMNSRTN GTIHFGVKDK
     PHGEIVGVQV TSKDIFVNHF NTMITKYFED SEISEARACI REPRFVEVLL QNNTQSNRFV
     IEVDVIPRHS ICQEKYFYIM MQSSTGKTWK QSKDTSLFVR EGASSKNILG NPNQRDREFK
     KFLEDLKMWT ASRKAAEEEL RMVTKKESEG LKLSKLLTRH QGSLDESYYD WYILVTNTCA
     PTQLEHLEFI KEMKLFAVLD FDPYSHIKGV VKAYRESRIA NLHLPSHYEE KTTIAEKIST
     LKLYEQPSWI FCNGRVDLSC QPLEPHLWQR DRASGVRRLI SFLTDENIIV KGKVLVVFLL
     LSPIENQKDP LIETFCAFYQ VFNGMDNMLC ICVNSAIYQQ WSDLLQVRLE IKDDLAKHSI
     STLNIELVNN TILKLKSVIQ SSRRFLPSCG SSSVILEKMD EDIMSALEIL CENECKDTDI
     EKDESQFLEF KKSREEHFYR GGRVSWWNFY FSSENYSSAF VKRDSFEELT TLIQQCADSP
     KPVFVKVINL YHHPGCGGTT LAMHVLWDLK QKFRCAVLKN KATDFVEIGE QVSKLMSYKA
     TSHEDFIPVL LLVDDFEEQE NAYILQNAIN AFIAEKGLRY EKTLVIILNC MRSQNPDESA
     KLANSISLKY QLSPKEQRAF EAKLQEIEKE HKNCENFYSF MILKGNFDTT YIKNVVKNTL
     KDLDAKSRRA QLISYLALLN SYVTDSTISV SQCEIFLGIT YTKKYGKPET VEKNMGTYST
     LLIRTEVSDY GRYTGIRIIH PLIATHCLKE LEMSYRMDKC QIALNMLEEN VLYDSGLGRD
     KFKYDVQTLL LTRQRKEHGA ETDTLFSPLI EELQNEETEK VLIAGSDRFP QNAFICQALA
     RHFYIKEKNF STALVWANLA KRKAPKNSYI SDTLGQVYKS ELNSGWEVAE KASKAFKESQ
     NQSDSKDYGT EAWSPQNSQR RYDTFNTAGF FGEIEVGLDT IQLLQLTPLF HKENEISKES
     MAEFLSGKGT ILSDPKGEYC VVLSKFTSLL QNLHSDLERC FHFFGDYMGF LKPRNTPKEL
     TELLLSKKVS RCFKKYVELF CHLDTNLVQG KEDLLLQKEN CRKRIQAWRA DTFSGLLEYL
     NPNHKEANNI ENIVGNYTFL LQDILNKQLS KVLTKDIQNF ILANIILSCL KPSSKYILPF
     STLKKKLREV LQIVGLTHSY PDPYFLACLL FWPENKELDE DSTLIEKYVS SLNRSFRRQY
     KHMCRSRQPS TLFYLGQKKG LNSLVHKAEI ERYFSEVQDS NSFWHSGVVW EKREVKDLLR
     LLDGQAEGKL ISLEYGTEAK IKIPVTSVYS APLRSGRNIE RVSFYLGFSI EGPLAYGIKV
     I