ID   SAMC_BOVIN              Reviewed;         274 AA.
AC   A6QR09;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=S-adenosylmethionine mitochondrial carrier protein;
DE   AltName: Full=Mitochondrial S-adenosylmethionine transporter;
DE   AltName: Full=Solute carrier family 25 member 26;
GN   Name=SLC25A26; Synonyms=SAMC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC       nucleotides, and cofactors through the mitochondrial inner membrane.
CC       Specifically mediates the transport of S-adenosylmethionine (SAM) into
CC       the mitochondria (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC150067; AAI50068.1; -; mRNA.
DR   RefSeq; NP_001096767.1; NM_001103297.1.
DR   AlphaFoldDB; A6QR09; -.
DR   SMR; A6QR09; -.
DR   STRING; 9913.ENSBTAP00000050467; -.
DR   PaxDb; A6QR09; -.
DR   PRIDE; A6QR09; -.
DR   Ensembl; ENSBTAT00000054584; ENSBTAP00000050467; ENSBTAG00000037972.
DR   GeneID; 614713; -.
DR   KEGG; bta:614713; -.
DR   CTD; 115286; -.
DR   VEuPathDB; HostDB:ENSBTAG00000037972; -.
DR   VGNC; VGNC:34752; SLC25A26.
DR   eggNOG; KOG0768; Eukaryota.
DR   GeneTree; ENSGT00550000074950; -.
DR   InParanoid; A6QR09; -.
DR   OMA; PRVGWIS; -.
DR   OrthoDB; 1538959at2759; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000037972; Expressed in oocyte and 107 other tissues.
DR   ExpressionAtlas; A6QR09; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0000095; F:S-adenosyl-L-methionine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015805; P:S-adenosyl-L-methionine transport; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 4.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; S-adenosyl-L-methionine; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..274
FT                   /note="S-adenosylmethionine mitochondrial carrier protein"
FT                   /id="PRO_0000317586"
FT   TRANSMEM        5..25
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          4..77
FT                   /note="Solcar 1"
FT   REPEAT          86..168
FT                   /note="Solcar 2"
FT   REPEAT          177..265
FT                   /note="Solcar 3"
SQ   SEQUENCE   274 AA;  29409 MW;  D0B86C6672135784 CRC64;
     MDRPGFTASL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF YKAGGFYGVY AGVPSTAIGS
     FPNAAAFFVT YEYVKWILHT DSSSYLMPVT HMLAASVGEV VACLIRVPSE VVKQRAQVSA
     SSGTFHIFSN ILCQEGIQGL YRGYKSTVLR EIPFSLVQFP LWESLKALWS WRQDRVVDSW
     QAAVCGAFAG GFAAAVTTPL DVAKTRIMLA KAGSSTASGN ILSALHAVWR TQGLSGLFAG
     VFPRMAAISL GGFIFLGVYD QTRSFLLELG RESP