ID   SAMC_DANRE              Reviewed;         267 AA.
AC   Q4V9P0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=S-adenosylmethionine mitochondrial carrier protein;
DE   AltName: Full=Mitochondrial S-adenosylmethionine transporter;
DE   AltName: Full=Solute carrier family 25 member 26;
GN   Name=slc25a26; Synonyms=samc; ORFNames=zgc:110080;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Egg, and Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC       nucleotides, and cofactors through the mitochondrial inner membrane.
CC       Specifically mediates the transport of S-adenosylmethionine (SAM) into
CC       the mitochondria (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC096793; AAH96793.1; -; mRNA.
DR   EMBL; BC153538; AAI53539.1; -; mRNA.
DR   RefSeq; NP_001025314.1; NM_001030143.1.
DR   AlphaFoldDB; Q4V9P0; -.
DR   STRING; 7955.ENSDARP00000075478; -.
DR   PaxDb; Q4V9P0; -.
DR   Ensembl; ENSDART00000081035; ENSDARP00000075478; ENSDARG00000058208.
DR   GeneID; 560478; -.
DR   KEGG; dre:560478; -.
DR   CTD; 115286; -.
DR   ZFIN; ZDB-GENE-050913-126; slc25a26.
DR   eggNOG; KOG0768; Eukaryota.
DR   GeneTree; ENSGT00550000074950; -.
DR   HOGENOM; CLU_015166_3_0_1; -.
DR   InParanoid; Q4V9P0; -.
DR   OMA; PRVGWIS; -.
DR   OrthoDB; 1538959at2759; -.
DR   PhylomeDB; Q4V9P0; -.
DR   TreeFam; TF313186; -.
DR   Reactome; R-DRE-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
DR   PRO; PR:Q4V9P0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000058208; Expressed in mature ovarian follicle and 26 other tissues.
DR   ExpressionAtlas; Q4V9P0; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0000095; F:S-adenosyl-L-methionine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015805; P:S-adenosyl-L-methionine transport; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 4.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; S-adenosyl-L-methionine; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..267
FT                   /note="S-adenosylmethionine mitochondrial carrier protein"
FT                   /id="PRO_0000317589"
FT   TRANSMEM        5..25
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          4..77
FT                   /note="Solcar 1"
FT   REPEAT          86..168
FT                   /note="Solcar 2"
FT   REPEAT          177..265
FT                   /note="Solcar 3"
SQ   SEQUENCE   267 AA;  28995 MW;  B7DF20E0D64E0813 CRC64;
     MDRREFTASL VAGGCAGMCV DLTLFPLDTI KTRLQSQQGF YKAGGFRGIY AGVPSAAIGS
     FPNAAAFFVT YESTKSVFSG YTTTNLAPIT HMLAASLGEI VACLIRVPTE VVKQRTQANP
     SISTYRVLLN SLQEEGFRGL YRGYGSTVLR EIPFSLVQFP LWEYLKAVWW RRQGGRLDSW
     QAAVCGALAG GVAAFVTTPL DVAKTWIMLA KAGTSTASGN IPMVLCEVWR SRGIPGLFAG
     SIPRVMFISM GGFIFLGAYE KVRRTLL