SAMC_MOUSE
ID SAMC_MOUSE Reviewed; 274 AA.
AC Q5U680; Q8JZT2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=S-adenosylmethionine mitochondrial carrier protein;
DE AltName: Full=Mitochondrial S-adenosylmethionine transporter;
DE AltName: Full=Solute carrier family 25 member 26;
GN Name=Slc25a26; Synonyms=Samc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, FVB/N, and FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC Specifically mediates the transport of S-adenosylmethionine (SAM) into
CC the mitochondria (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC019156; AAH19156.1; -; mRNA.
DR EMBL; BC019170; AAH19170.1; -; mRNA.
DR EMBL; BC037142; AAH37142.1; -; mRNA.
DR CCDS; CCDS20379.1; -.
DR RefSeq; NP_080531.2; NM_026255.5.
DR AlphaFoldDB; Q5U680; -.
DR STRING; 10090.ENSMUSP00000058028; -.
DR PhosphoSitePlus; Q5U680; -.
DR EPD; Q5U680; -.
DR MaxQB; Q5U680; -.
DR PaxDb; Q5U680; -.
DR PeptideAtlas; Q5U680; -.
DR PRIDE; Q5U680; -.
DR ProteomicsDB; 256697; -.
DR Antibodypedia; 15419; 111 antibodies from 19 providers.
DR DNASU; 67582; -.
DR Ensembl; ENSMUST00000061118; ENSMUSP00000058028; ENSMUSG00000045100.
DR GeneID; 67582; -.
DR KEGG; mmu:67582; -.
DR UCSC; uc009czr.2; mouse.
DR CTD; 115286; -.
DR MGI; MGI:1914832; Slc25a26.
DR VEuPathDB; HostDB:ENSMUSG00000045100; -.
DR eggNOG; KOG0768; Eukaryota.
DR GeneTree; ENSGT00550000074950; -.
DR HOGENOM; CLU_015166_3_0_1; -.
DR InParanoid; Q5U680; -.
DR OMA; PRVGWIS; -.
DR OrthoDB; 1538959at2759; -.
DR PhylomeDB; Q5U680; -.
DR TreeFam; TF313186; -.
DR Reactome; R-MMU-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
DR BioGRID-ORCS; 67582; 20 hits in 72 CRISPR screens.
DR ChiTaRS; Slc25a26; mouse.
DR PRO; PR:Q5U680; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q5U680; protein.
DR Bgee; ENSMUSG00000045100; Expressed in interventricular septum and 222 other tissues.
DR ExpressionAtlas; Q5U680; baseline and differential.
DR Genevisible; Q5U680; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0000095; F:S-adenosyl-L-methionine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015805; P:S-adenosyl-L-methionine transport; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; S-adenosyl-L-methionine; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..274
FT /note="S-adenosylmethionine mitochondrial carrier protein"
FT /id="PRO_0000317588"
FT TRANSMEM 5..25
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 4..77
FT /note="Solcar 1"
FT REPEAT 86..168
FT /note="Solcar 2"
FT REPEAT 177..265
FT /note="Solcar 3"
FT CONFLICT 262
FT /note="A -> T (in Ref. 1; AAH19156)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 274 AA; 29027 MW; 35C2828A51D793CB CRC64;
MDAPGFTASL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFRGIY AGVPSAAVGS
FPNAAAFFLT YEYVKSLLHT DSTSHFKPVK HMLAASTGEV VACLIRVPSE VVKQRAQVSA
SSKTLQIFLT ILSEEGIQGL YRGYKSTVLR EIPFSLVQFP LWESLKALWA WRRGHVVDSW
QSAVCGAFAG GFAAAVTTPL DVAKTRIMLA KAGSSTAVGN VLSAMHGVWR SQGLAGLFAG
VLPRMAAISM GGFIFLGAYD QARSLLLEVG RKSP
