SAMC_XENLA
ID SAMC_XENLA Reviewed; 266 AA.
AC Q641C8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=S-adenosylmethionine mitochondrial carrier protein;
DE AltName: Full=Mitochondrial S-adenosylmethionine transporter;
DE AltName: Full=Solute carrier family 25 member 26;
GN Name=slc25a26; Synonyms=samc;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC Specifically mediates the transport of S-adenosylmethionine (SAM) into
CC the mitochondria (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC082409; AAH82409.1; -; mRNA.
DR EMBL; BC130059; AAI30060.1; -; mRNA.
DR RefSeq; NP_001087879.1; NM_001094410.1.
DR AlphaFoldDB; Q641C8; -.
DR SMR; Q641C8; -.
DR DNASU; 447740; -.
DR GeneID; 447740; -.
DR KEGG; xla:447740; -.
DR CTD; 447740; -.
DR Xenbase; XB-GENE-991476; slc25a26.L.
DR OrthoDB; 1538959at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 447740; Expressed in oocyte and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0000095; F:S-adenosyl-L-methionine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015805; P:S-adenosyl-L-methionine transport; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 4.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; S-adenosyl-L-methionine; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..266
FT /note="S-adenosylmethionine mitochondrial carrier protein"
FT /id="PRO_0000317590"
FT TRANSMEM 5..25
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 4..77
FT /note="Solcar 1"
FT REPEAT 85..167
FT /note="Solcar 2"
FT REPEAT 176..264
FT /note="Solcar 3"
SQ SEQUENCE 266 AA; 28683 MW; CC12377BE188F114 CRC64;
MERRELCASL LAGGAAGMSV DLILFPLDTI KTRLQSPLGF SKSGGFRGIY AGVPSTAVGS
FPNAAAFFVT YESAKRFLGS DSSYLSPIIH MAAAFLGELV ACLIRVPSEV IKQRAQVSPS
STTYQMLSVT LREEGIKGLY RGYKSTVLRE IPFSLVQFPL WEFLKNLWSW KQGRAVDCWQ
SAVCGAFAGG FAAAVTTPLD VAKTRIMLAK AGSGVANGNV LFALHEIWRT QGIMGLFAGV
IPRMTMISLG GFIFLGAYDK VRSSLL
