SAMC_XENTR
ID SAMC_XENTR Reviewed; 269 AA.
AC Q6GLA2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=S-adenosylmethionine mitochondrial carrier protein;
DE AltName: Full=Mitochondrial S-adenosylmethionine transporter;
DE AltName: Full=Solute carrier family 25 member 26;
GN Name=slc25a26; Synonyms=samc;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC Specifically mediates the transport of S-adenosylmethionine (SAM) into
CC the mitochondria (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC074600; AAH74600.1; -; mRNA.
DR RefSeq; NP_001004820.1; NM_001004820.1.
DR AlphaFoldDB; Q6GLA2; -.
DR SMR; Q6GLA2; -.
DR STRING; 8364.ENSXETP00000056365; -.
DR PaxDb; Q6GLA2; -.
DR DNASU; 448074; -.
DR GeneID; 448074; -.
DR KEGG; xtr:448074; -.
DR CTD; 115286; -.
DR Xenbase; XB-GENE-991471; slc25a26.
DR eggNOG; KOG0768; Eukaryota.
DR InParanoid; Q6GLA2; -.
DR OrthoDB; 1538959at2759; -.
DR Reactome; R-XTR-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0000095; F:S-adenosyl-L-methionine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015805; P:S-adenosyl-L-methionine transport; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 4.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; S-adenosyl-L-methionine; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..269
FT /note="S-adenosylmethionine mitochondrial carrier protein"
FT /id="PRO_0000317591"
FT TRANSMEM 5..25
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 4..77
FT /note="Solcar 1"
FT REPEAT 85..167
FT /note="Solcar 2"
FT REPEAT 176..264
FT /note="Solcar 3"
SQ SEQUENCE 269 AA; 29020 MW; D23A798DCDDE1863 CRC64;
MERREFCASL LAGGTAGMCV DLILFPLDTI KTRLQSPLGF SKSGGFRGIY AGVPSTAVGS
FPNAAAFFVT YESAKQLLRS DSSYLSPIIH MAAASLGEVV ACLIRVPSEV IKQRAQVSPS
STTYQMLSAT LRQEGIKGLY RGYKSTVLRE IPFSLVQFPL WESLKDLWSW KQGRAVDSWQ
SAVCGAFAGG FAAALTTPLD VAKTRIMLAK AGSGVASGNV LFALHEIWRT QGIMGLFAGV
IPRMTAISLG GFIFLGAYDK VRTLMLREQ
