SAMD3_MOUSE
ID SAMD3_MOUSE Reviewed; 520 AA.
AC Q8C4H2; E9QPH5;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Sterile alpha motif domain-containing protein 3;
DE Short=SAM domain-containing protein 3;
GN Name=Samd3; Synonyms=Gm623;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C4H2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C4H2-2; Sequence=VSP_041628, VSP_041629;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC38435.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK082201; BAC38435.1; ALT_INIT; mRNA.
DR EMBL; AC091763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48524.1; -. [Q8C4H2-2]
DR RefSeq; NP_001013788.2; NM_001013766.2. [Q8C4H2-2]
DR RefSeq; NP_001108626.1; NM_001115154.1.
DR RefSeq; XP_006512810.1; XM_006512747.3.
DR AlphaFoldDB; Q8C4H2; -.
DR SMR; Q8C4H2; -.
DR BioGRID; 234476; 2.
DR IntAct; Q8C4H2; 1.
DR STRING; 10090.ENSMUSP00000057805; -.
DR PhosphoSitePlus; Q8C4H2; -.
DR PaxDb; Q8C4H2; -.
DR PRIDE; Q8C4H2; -.
DR Antibodypedia; 32851; 117 antibodies from 19 providers.
DR Ensembl; ENSMUST00000164660; ENSMUSP00000129054; ENSMUSG00000051354. [Q8C4H2-2]
DR GeneID; 268288; -.
DR KEGG; mmu:268288; -.
DR UCSC; uc007ery.1; mouse. [Q8C4H2-2]
DR CTD; 154075; -.
DR MGI; MGI:2685469; Samd3.
DR VEuPathDB; HostDB:ENSMUSG00000051354; -.
DR eggNOG; KOG1945; Eukaryota.
DR GeneTree; ENSGT00390000012396; -.
DR HOGENOM; CLU_088445_0_0_1; -.
DR InParanoid; Q8C4H2; -.
DR OrthoDB; 439825at2759; -.
DR BioGRID-ORCS; 268288; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Samd3; mouse.
DR PRO; PR:Q8C4H2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8C4H2; protein.
DR Bgee; ENSMUSG00000051354; Expressed in facial bone primordium and 36 other tissues.
DR ExpressionAtlas; Q8C4H2; baseline and differential.
DR CDD; cd09526; SAM_Samd3; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR042812; SAMD3.
DR InterPro; IPR042813; SAMD3_SAM.
DR PANTHER; PTHR47302; PTHR47302; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..520
FT /note="Sterile alpha motif domain-containing protein 3"
FT /id="PRO_0000279497"
FT DOMAIN 4..71
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 67..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 271..273
FT /note="EES -> PSA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_041628"
FT VAR_SEQ 274..520
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_041629"
SQ SEQUENCE 520 AA; 60419 MW; 491032E4BB3177CE CRC64;
METWSVDQVC KWLVEKNLGE LVPRFQEEEV SGATLLALND RMVQQLVKKI GHQAVLMDFI
KKYKQGNQEL KPTGGPADTS TLTPAQAAPE HEQNPSPTSH GDQTSLYPAV LDNRLIDQRV
LKQRRNVKHV LARHKALQWT KSYILPEFPY DVKCMLVEQK RPDHSMRIRI IEFLQADMTK
YLEGSLYPTT QQYNDVVNAL LQAHPFLDED GCGFFLWKRA LKDRFKYIRR PIEDDEQVMR
NKCKFGHRRG QTRKSLADIQ SNEIKIVQIK EESAHLDSEV DEHISWFQQE YMKTERDWRE
VDKRMSQTLE IRRKMIGGQT PLKDILKMFP FLKCPYQMFR EVQILTKTDI YKKTRHILES
YSENILTAFS VLDNPINTAL QEKMKHYTDE GVLKSPEVLK NMKMTATCLL LPHVFGDEPS
LFVVVNGKVH VSTPVLEVKN PFHINGCEFS LYLNKEKLTK VDDCVTALAA LVSAFRVFGI
ECPRRLSQTF NFLETLIFDM QSPQFPSLKE KEIRSQPPIT
