ID   SAMD5_HUMAN             Reviewed;         173 AA.
AC   Q5TGI4;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Sterile alpha motif domain-containing protein 5;
DE            Short=SAM domain-containing protein 5;
GN   Name=SAMD5; Synonyms=SAMDC1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=28388653; DOI=10.1371/journal.pone.0175355;
RA   Yagai T., Matsui S., Harada K., Inagaki F.F., Saijou E., Miura Y.,
RA   Nakanuma Y., Miyajima A., Tanaka M.;
RT   "Expression and localization of sterile alpha motif domain containing 5 is
RT   associated with cell type and malignancy of biliary tree.";
RL   PLoS ONE 12:E0175355-E0175355(2017).
CC   -!- SUBUNIT: Interacts promiscuously (via SAM domain) with EPHA5, EPHA6,
CC       EPHA7, EPHA8, EPHB1, EPHB2, EPHB3 and EPHB4 (via SAM domain) (in
CC       vitro). {ECO:0000250|UniProtKB:Q3V1H9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28388653}.
CC   -!- TISSUE SPECIFICITY: Detected in biliary epithelial cells on bile ducts
CC       at the hepatic hilum (at protein level). {ECO:0000269|PubMed:28388653}.
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DR   EMBL; AL354880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL034350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS34548.1; -.
DR   RefSeq; NP_001025231.1; NM_001030060.2.
DR   AlphaFoldDB; Q5TGI4; -.
DR   SMR; Q5TGI4; -.
DR   BioGRID; 133149; 1.
DR   STRING; 9606.ENSP00000356444; -.
DR   iPTMnet; Q5TGI4; -.
DR   PhosphoSitePlus; Q5TGI4; -.
DR   BioMuta; SAMD5; -.
DR   DMDM; 74746493; -.
DR   jPOST; Q5TGI4; -.
DR   MassIVE; Q5TGI4; -.
DR   PaxDb; Q5TGI4; -.
DR   PeptideAtlas; Q5TGI4; -.
DR   PRIDE; Q5TGI4; -.
DR   Antibodypedia; 74954; 4 antibodies from 4 providers.
DR   DNASU; 389432; -.
DR   Ensembl; ENST00000367474.2; ENSP00000356444.1; ENSG00000203727.4.
DR   GeneID; 389432; -.
DR   KEGG; hsa:389432; -.
DR   MANE-Select; ENST00000367474.2; ENSP00000356444.1; NM_001030060.3; NP_001025231.1.
DR   UCSC; uc003qmc.3; human.
DR   CTD; 389432; -.
DR   DisGeNET; 389432; -.
DR   GeneCards; SAMD5; -.
DR   HGNC; HGNC:21180; SAMD5.
DR   HPA; ENSG00000203727; Low tissue specificity.
DR   neXtProt; NX_Q5TGI4; -.
DR   OpenTargets; ENSG00000203727; -.
DR   PharmGKB; PA134888862; -.
DR   VEuPathDB; HostDB:ENSG00000203727; -.
DR   eggNOG; KOG4384; Eukaryota.
DR   GeneTree; ENSGT00510000048701; -.
DR   HOGENOM; CLU_115568_1_0_1; -.
DR   InParanoid; Q5TGI4; -.
DR   OMA; LEFLMNW; -.
DR   OrthoDB; 1498045at2759; -.
DR   PhylomeDB; Q5TGI4; -.
DR   TreeFam; TF339222; -.
DR   PathwayCommons; Q5TGI4; -.
DR   SignaLink; Q5TGI4; -.
DR   BioGRID-ORCS; 389432; 15 hits in 1069 CRISPR screens.
DR   ChiTaRS; SAMD5; human.
DR   GenomeRNAi; 389432; -.
DR   Pharos; Q5TGI4; Tdark.
DR   PRO; PR:Q5TGI4; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5TGI4; protein.
DR   Bgee; ENSG00000203727; Expressed in kidney epithelium and 148 other tissues.
DR   ExpressionAtlas; Q5TGI4; baseline and differential.
DR   Genevisible; Q5TGI4; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..173
FT                   /note="Sterile alpha motif domain-containing protein 5"
FT                   /id="PRO_0000311361"
FT   DOMAIN          1..65
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          75..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  19231 MW;  6869A7A22FD73745 CRC64;
     MCTNIVYEWL KALQLPQYAE SFVDNGYDDL EVCKQIGDPD LDAIGVLAPA HRRRILEAVR
     RLREQDANAA GLYFTLEPQP APPGPPADAV PTGRRGEPCG GPAQGTRGDS RGHTTAPRSR
     ELVSYPKLKL KIMIRDKLVR DGIHLSKPPY SRKVPMAGIL EYLMNWPKSS QSR