SAMD7_MOUSE
ID SAMD7_MOUSE Reviewed; 445 AA.
AC Q8C8Y5; F8WHA0; G3UXH0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2017, sequence version 4.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Sterile alpha motif domain-containing protein 7;
DE Short=SAM domain-containing protein 7;
GN Name=Samd7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-181 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Retina;
RA Ida H., Boylan S., Weigel A., Smit-McBride Z., Chao A., Gao J., Buchoff P.,
RA Wistow G., Hjelmeland L.;
RT "Expressed sequence tag analysis of mouse retina.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INDUCTION BY CRX.
RX PubMed=23565263; DOI=10.1371/journal.pone.0060633;
RA Hlawatsch J., Karlstetter M., Aslanidis A., Lueckoff A., Walczak Y.,
RA Plank M., Boeck J., Langmann T.;
RT "Sterile alpha motif containing 7 (samd7) is a novel crx-regulated
RT transcriptional repressor in the retina.";
RL PLoS ONE 8:E60633-E60633(2013).
CC -!- FUNCTION: Involved in the regulation of gene expression in the retina.
CC It functions as a negative regulator of CRX-controlled genes.
CC {ECO:0000269|PubMed:23565263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23565263}. Cytoplasm
CC {ECO:0000269|PubMed:23565263}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C8Y5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C8Y5-3; Sequence=VSP_059092, VSP_059093;
CC -!- TISSUE SPECIFICITY: Expressed in the retina and the pineal gland. In
CC the retina, it is predominantly expressed in the outer nuclear layer.
CC {ECO:0000269|PubMed:23565263}.
CC -!- INDUCTION: Transcriptionally regulated by CRX.
CC {ECO:0000269|PubMed:23565263}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31828.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AK044227; BAC31828.1; ALT_SEQ; mRNA.
DR EMBL; AC158135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CK618776; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS17285.2; -. [Q8C8Y5-1]
DR RefSeq; NP_083765.2; NM_029489.3. [Q8C8Y5-1]
DR RefSeq; XP_017175280.1; XM_017319791.1. [Q8C8Y5-1]
DR AlphaFoldDB; Q8C8Y5; -.
DR SMR; Q8C8Y5; -.
DR STRING; 10090.ENSMUSP00000103897; -.
DR PhosphoSitePlus; Q8C8Y5; -.
DR jPOST; Q8C8Y5; -.
DR PaxDb; Q8C8Y5; -.
DR PRIDE; Q8C8Y5; -.
DR ProteomicsDB; 256698; -. [Q8C8Y5-1]
DR ProteomicsDB; 256699; -. [Q8C8Y5-3]
DR Antibodypedia; 51043; 149 antibodies from 14 providers.
DR DNASU; 75953; -.
DR Ensembl; ENSMUST00000108262; ENSMUSP00000103897; ENSMUSG00000051860. [Q8C8Y5-1]
DR Ensembl; ENSMUST00000174395; ENSMUSP00000133687; ENSMUSG00000051860. [Q8C8Y5-3]
DR GeneID; 75953; -.
DR KEGG; mmu:75953; -.
DR UCSC; uc008ovg.2; mouse. [Q8C8Y5-1]
DR CTD; 344658; -.
DR MGI; MGI:1923203; Samd7.
DR VEuPathDB; HostDB:ENSMUSG00000051860; -.
DR eggNOG; KOG3829; Eukaryota.
DR GeneTree; ENSGT00940000160075; -.
DR InParanoid; Q8C8Y5; -.
DR OMA; MLYMMNL; -.
DR OrthoDB; 622508at2759; -.
DR PhylomeDB; Q8C8Y5; -.
DR TreeFam; TF331299; -.
DR BioGRID-ORCS; 75953; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8C8Y5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8C8Y5; protein.
DR Bgee; ENSMUSG00000051860; Expressed in retinal neural layer and 40 other tissues.
DR ExpressionAtlas; Q8C8Y5; baseline and differential.
DR Genevisible; F8WHA0; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..445
FT /note="Sterile alpha motif domain-containing protein 7"
FT /id="PRO_0000263103"
FT DOMAIN 324..378
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 193..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 34..39
FT /note="DVLSSS -> LGHFTT (in isoform 2)"
FT /id="VSP_059092"
FT VAR_SEQ 40..445
FT /note="Missing (in isoform 2)"
FT /id="VSP_059093"
SQ SEQUENCE 445 AA; 49259 MW; B861CEA5D859B812 CRC64;
MTNPMMSVSS LLTSGQQKVP MVPSPFGPPI VDRDVLSSSI APTDPSQFCV PSQFGSSGLP
NANMPNPLSS HFYSGWGILP PEPIKAVTTR NEMFERHHAA RAEMEMYSLY QQRRMERVNP
KGLSGLGIPL FYGSSCLGGP TGFQGRSTLP ASDVHLHRST FRHLQGNPIL LATRPHFTEC
WGQKYRLRRG AVYQKPPESD TESFKSQAEE KSSSQMPTLS YEEEEYIKDP DIEVDNQQKP
RVADGKPTTV PANPHGELHT HQRKPSSLEA NAWDDGKGKP SEQVYEGCDG KNGVFRPVSI
LPLSGTHEQV ALRENCSLSD IQKWTVDDVY NFIRSLPGCS DYAQVFKDHA IDGETLPLLT
EQHLRGTMGL KLGPALKIQS QVSQHVGNMF CKKLPSLPTH ARQAFDQPAD TSPLLDMSSW
SDGLSIPGPQ DLLSPKRTEQ DVMRN
