ID   SAMHT_CHLMU             Reviewed;         318 AA.
AC   Q9PJG0;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=S-adenosylmethionine/S-adenosylhomocysteine transporter;
DE            Short=SAM/SAH transporter;
DE            Short=SAMHT;
GN   OrderedLocusNames=TC_0869;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: Transports S-adenosylmethionine (SAM) and S-
CC       adenosylhomocysteine (SAH). Allows bacteria to acquire SAM from the
CC       eukaryotic host cell and to likely remove the toxic by-product SAH (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC       {ECO:0000305}.
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DR   EMBL; AE002160; AAF39665.1; -; Genomic_DNA.
DR   PIR; H81655; H81655.
DR   AlphaFoldDB; Q9PJG0; -.
DR   SMR; Q9PJG0; -.
DR   STRING; 243161.TC_0869; -.
DR   EnsemblBacteria; AAF39665; AAF39665; TC_0869.
DR   KEGG; cmu:TC_0869; -.
DR   eggNOG; COG0697; Bacteria.
DR   HOGENOM; CLU_080359_0_0_0; -.
DR   OMA; AYGLFFY; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..318
FT                   /note="S-adenosylmethionine/S-adenosylhomocysteine
FT                   transporter"
FT                   /id="PRO_0000414247"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          25..148
FT                   /note="EamA 1"
FT   DOMAIN          191..304
FT                   /note="EamA 2"
SQ   SEQUENCE   318 AA;  35317 MW;  48CA6FD367299B6E CRC64;
     MMLVLRFANL YVEPMAIFLI FLNAFIWSSS FALSKSAMDA ASPLFVTGSR MVLAGIVLFG
     LLLFKRESFR LPRQAVMPIV LLSVIGFYLT NVLEFIGLQG LSSSKACFIY GFSPFTAAFC
     SYVQLREVVT WKKLGGLSLG LVSYLVYLLF GGGEDVSEWG WQLGMPELLL IVATCLSSYG
     WTLLRKLERQ CESLSITAIN AYAMVIAGIL SLAHSAITEV WNPLPVENPV LFLQSIGALV
     IFSNLICYNL FAKLLRSFSS TFLSFCNLVM PLFASFFGWL LLGESFPPGL LFAVGFMVLG
     CRLIYHEEFR QGYVLSSE