SAMTR_DROME
ID SAMTR_DROME Reviewed; 302 AA.
AC Q9W138;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=S-adenosylmethionine sensor upstream of mTORC1 {ECO:0000255|HAMAP-Rule:MF_03044, ECO:0000303|PubMed:29123071};
DE Short=dSamtor {ECO:0000303|PubMed:29123071};
DE AltName: Full=Probable methyltransferase BMT2 homolog {ECO:0000255|HAMAP-Rule:MF_03044};
DE EC=2.1.1.- {ECO:0000255|HAMAP-Rule:MF_03044};
GN Name=Samtor {ECO:0000303|PubMed:29123071}; ORFNames=CG3570;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION.
RX PubMed=29123071; DOI=10.1126/science.aao3265;
RA Gu X., Orozco J.M., Saxton R.A., Condon K.J., Liu G.Y., Krawczyk P.A.,
RA Scaria S.M., Harper J.W., Gygi S.P., Sabatini D.M.;
RT "SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.";
RL Science 358:813-818(2017).
CC -!- FUNCTION: S-adenosyl-L-methionine-binding protein that acts as an
CC inhibitor of mTORC1 signaling (PubMed:29123071). Acts as a sensor of S-
CC adenosyl-L-methionine to signal methionine sufficiency to mTORC1
CC (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-
CC dependent methyltransferase. {ECO:0000255|HAMAP-Rule:MF_03044,
CC ECO:0000269|PubMed:29123071}.
CC -!- SIMILARITY: Belongs to the BMT2 family. {ECO:0000255|HAMAP-
CC Rule:MF_03044}.
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DR EMBL; AE013599; AAF47239.1; -; Genomic_DNA.
DR EMBL; AY051416; AAK92840.1; -; mRNA.
DR RefSeq; NP_611943.1; NM_138099.3.
DR AlphaFoldDB; Q9W138; -.
DR BioGRID; 63506; 1.
DR IntAct; Q9W138; 1.
DR STRING; 7227.FBpp0072224; -.
DR PaxDb; Q9W138; -.
DR PRIDE; Q9W138; -.
DR DNASU; 37934; -.
DR EnsemblMetazoa; FBtr0072317; FBpp0072224; FBgn0035035.
DR GeneID; 37934; -.
DR KEGG; dme:Dmel_CG3570; -.
DR UCSC; CG3570-RA; d. melanogaster.
DR CTD; 37934; -.
DR FlyBase; FBgn0035035; Samtor.
DR VEuPathDB; VectorBase:FBgn0035035; -.
DR eggNOG; ENOG502QRK4; Eukaryota.
DR GeneTree; ENSGT00390000010382; -.
DR HOGENOM; CLU_036404_0_0_1; -.
DR InParanoid; Q9W138; -.
DR OMA; PHLEVTA; -.
DR OrthoDB; 836637at2759; -.
DR PhylomeDB; Q9W138; -.
DR SignaLink; Q9W138; -.
DR BioGRID-ORCS; 37934; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37934; -.
DR PRO; PR:Q9W138; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0035035; Expressed in adult abdomen and 21 other tissues.
DR Genevisible; Q9W138; DM.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IMP:UniProtKB.
DR Gene3D; 3.40.50.150; -; 1.
DR HAMAP; MF_03044; BMT2; 1.
DR InterPro; IPR021867; Bmt2/SAMTOR.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR21008; PTHR21008; 1.
DR Pfam; PF11968; Bmt2; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..302
FT /note="S-adenosylmethionine sensor upstream of mTORC1"
FT /id="PRO_0000321545"
FT BINDING 132
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03044"
FT BINDING 150
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03044"
SQ SEQUENCE 302 AA; 34819 MW; 05C8E066BFA3343F CRC64;
MATEEHQRLA SIVKSCHESL RQLTKEYGAT AAWQEHTSPR NAKQLAEYAK AMKQLAAIWE
TNDGKVELQA RSRIKWAIDY ITKYFFTEGI YLQKRQREQR LLESYRAEGK LGEVQCRLME
EPPDRLHVLD VGSCFNPFSS APHLEVTALD LCPATEDVLQ ADFLKVEVVP GIREPELEEG
SVRRLPASHY ECVIFSLLLE YMPSAEQRLQ CCLQAYDLLL PEGILVLITP DSQHVGKNAH
LMKNWRYSLA RIGLLRVRFE KLPHISCMVF RKAISRELSQ HWASIHREEG MCEEIRIPQD
DS
