ID   SAM_RICCN               Reviewed;         294 AA.
AC   Q92JG1;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=S-adenosylmethionine uptake transporter;
GN   Name=sam; OrderedLocusNames=RC0106;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: Transports S-adenosylmethionine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
CC       {ECO:0000305}.
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DR   EMBL; AE006914; AAL02644.1; -; Genomic_DNA.
DR   PIR; B97713; B97713.
DR   RefSeq; WP_004996775.1; NC_003103.1.
DR   AlphaFoldDB; Q92JG1; -.
DR   SMR; Q92JG1; -.
DR   EnsemblBacteria; AAL02644; AAL02644; RC0106.
DR   KEGG; rco:RC0106; -.
DR   HOGENOM; CLU_032828_0_0_5; -.
DR   OMA; PFFWEVP; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..294
FT                   /note="S-adenosylmethionine uptake transporter"
FT                   /id="PRO_0000280995"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          21..141
FT                   /note="EamA 1"
FT   DOMAIN          160..280
FT                   /note="EamA 2"
SQ   SEQUENCE   294 AA;  33071 MW;  48DDFD6B00D28104 CRC64;
     MNDALKTYLT GIGWFLLSLV SSSANDVISK YLGTRLHSFE VAFFRFFFSS IVLLPFVVYY
     GKNTLKTSRP FVHILRGLLL FFGMTSWTYG LTIAPVTTAT VVSFSIPLFT LILAVFFLNE
     NIIWPRWVVT VVGFIGLVVT LKPHAEDFNP EILYFVLAAI SFAMLDIINK KFVIKESMIS
     MLFYSAIVTA IVSLPVASQY WLTPSSFELA LLFVLGSSGS LILFFLLKAF SMVDATATAP
     YRYLELVISV IAAYFIFNEF PDKSTLHGAV IIIPTTLFII YSEKKAMNRK HESQ